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Tchem
CLCN6
Chloride transport protein 6

Protein Summary
Description
Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor binding site profile
0.75
small molecule perturbation
0.68
virus perturbation
0.68
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
DIDS
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
NT-proBNP measurement
1
1
1
82.6
sex hormone-binding globulin measurement
2
1
2
79.7
mean corpuscular hemoglobin concentration
1
1
1
78.9
low density lipoprotein cholesterol measurement
1
1
1
51.6
red blood cell distribution width
1
1
1
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
NT-proBNP measurement
1
82.6
sex hormone-binding globulin measurement
2
79.7
mean corpuscular hemoglobin concentration
1
78.9
low density lipoprotein cholesterol measurement
1
51.6
red blood cell distribution width
1
46.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 6
VGNC:10576
457955
Macaque
chloride voltage-gated channel 6
714793
Mouse
MGI:1347049
26372
Rat
RGD:1305379
295586
Dog
chloride voltage-gated channel 6
VGNC:39306
478229
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 6
Macaque
chloride voltage-gated channel 6
Mouse
Rat
Dog
chloride voltage-gated channel 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51797-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Ion channel transport
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Ion channel transport
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.999999909
p_ni: 8.2e-8
p_wrong: 8e-9
Data Source: BioPlex
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.99999199
p_ni: 0.000001044
p_wrong: 0.000006966
Score: 0.538
Data Source: BioPlex,STRINGDB
FAM131B
Tdark
Novelty: 0.3424123
Score: 0.968
Data Source: STRINGDB
KIAA1549
Tbio
Novelty: 0.01224835
Score: 0.956
Data Source: STRINGDB
AGTRAP
Tbio
Novelty: 0.02295361
Score: 0.955
Data Source: STRINGDB
QKI
Tbio
Novelty: 0.00966983
Score: 0.924
Data Source: STRINGDB
FXR1
Tbio
Novelty: 0.01279428
Score: 0.921
Data Source: STRINGDB
AGGF1
Tbio
Novelty: 0.02757407
Score: 0.917
Data Source: STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
Score: 0.917
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.37

PubMed score by year
PubTator Score  16.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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