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Tchem
CLCN4
H(+)/Cl(-) exchange transporter 4

Protein Summary
Description
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380833
  • ENSP00000370213
  • ENSG00000073464
  • ENST00000421085
  • ENSP00000405754

Symbol
  • CLC4
  • ClC-4
  • MRX15
  • MRX49
  • ClC-4A
  • MRXSRC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase perturbation
0.84
transcription factor perturbation
0.8
disease perturbation
0.74
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (46)
IL1RAPL1
Tbio
Novelty:  0.01364357
Score:  0.694
Data Source:  STRINGDB
ARX
Tbio
Family:  TF
Novelty:  0.0080969
Score:  0.657
Data Source:  STRINGDB
VCX3B
Tdark
Novelty:  0.36671023
Score:  0.644
Data Source:  STRINGDB
SHOX
Tbio
Family:  TF
Novelty:  0.00259568
Score:  0.641
Data Source:  STRINGDB
VCX2
Tdark
Novelty:  0.37435639
Score:  0.64
Data Source:  STRINGDB
AMELX
Tbio
Novelty:  0.00063284
Score:  0.64
Data Source:  STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
Score:  0.637
Data Source:  STRINGDB
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
Score:  0.634
Data Source:  STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
Score:  0.627
Data Source:  STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
Score:  0.603
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104571
12727
Rat
RGD:708381
60586
Dog
chloride voltage-gated channel 4
VGNC:39304
491736
Horse
chloride voltage-gated channel 4
VGNC:16578
100049933
Cow
chloride voltage-gated channel 4
VGNC:27398
511699
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
chloride voltage-gated channel 4
Horse
chloride voltage-gated channel 4
Cow
chloride voltage-gated channel 4
Publication Statistics
PubMed Score 54.19
PubMed score by year
PubTator Score 25.80
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title