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Tchem
CLCN3
H(+)/Cl(-) exchange transporter 3

Protein Summary
Description
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347613
  • ENSP00000261514
  • ENSG00000109572
  • ENST00000360642
  • ENSP00000353857
  • ENST00000513761
  • ENSP00000424603

Symbol
  • CLC3
  • ClC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
1
virus perturbation
1
co-expressed gene
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.96   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.96   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (72)
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.412
Data Source:  BioPlex,STRINGDB
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.677
Data Source:  BioPlex,STRINGDB
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999999925
p_ni:  7.5e-8
Score:  0.571
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999999091
p_ni:  9.09e-7
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999965819
p_ni:  0.000034181
Score:  0.209
Data Source:  BioPlex,STRINGDB
CLCN5
Tbio
Family:  IC
Novelty:  0.00419772
p_int:  0.999910019
p_ni:  0.00008998
p_wrong:  1e-9
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999790524
p_ni:  0.0002093
p_wrong:  1.77e-7
Score:  0.217
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.997947216
p_ni:  0.002045274
p_wrong:  0.00000751
Score:  0.172
Data Source:  BioPlex,STRINGDB
GPM6A
Tbio
Novelty:  0.04123799
Score:  0.807
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
0
1.1
58.2
1
1
0
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.2
0
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 3
VGNC:7416
471346
Macaque
chloride voltage-gated channel 3
694472
Mouse
MGI:103555
12725
Rat
RGD:621219
84360
Dog
chloride voltage-gated channel 3
VGNC:39303
477354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 3
Macaque
chloride voltage-gated channel 3
Mouse
Rat
Dog
chloride voltage-gated channel 3
Publication Statistics
PubMed Score 269.96
PubMed score by year
PubTator Score 108.16
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title