CLCN2
Chloride channel protein 2
Protein Summary
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
- ENST00000265593
- ENSP00000265593
- ENSG00000114859
- ENST00000344937
- ENSP00000345056
- ENST00000434054
- ENSP00000400425
- ENST00000457512
- ENSP00000391928
- CLC2
- ECA2
- ECA3
- EGI3
- EGMA
- EJM6
- EJM8
- CIC-2
- EGI11
- HALD2
- LKPAT
- clC-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.79 | ||
transcription factor binding site profile | 0.79 | ||
transcription factor | 0.78 | ||
molecular function | 0.7 | ||
histone modification site profile | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 145.34 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 269 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 145.34 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 269 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1