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Tclin
CLCN2
Chloride channel protein 2

Protein Summary
Description
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265593
  • ENSP00000265593
  • ENSG00000114859
  • ENST00000344937
  • ENSP00000345056
  • ENST00000434054
  • ENSP00000400425
  • ENST00000457512
  • ENSP00000391928

Symbol
  • CLC2
  • ECA2
  • ECA3
  • EGI3
  • EGMA
  • EJM6
  • EJM8
  • CIC-2
  • EGI11
  • HALD2
  • LKPAT
  • clC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.79
transcription factor binding site profile
0.79
transcription factor
0.78
molecular function
0.7
histone modification site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.17   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.17   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lubiprostone
Rendered image for lubiprostone
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
9
12
99.5
platelet count
5
9
15
99.4
appendicular lean mass
4
2
4
92.2
hematological measurement
1
1
1
84.2
daytime rest measurement
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
12
99.5
platelet count
15
99.4
appendicular lean mass
4
92.2
hematological measurement
1
84.2
daytime rest measurement
1
74.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chloride voltage-gated channel 2
704709
Mouse
MGI:105061
12724
Dog
chloride voltage-gated channel 2
VGNC:39302
488106
Horse
chloride voltage-gated channel 2
VGNC:16576
100067143
Cow
chloride voltage-gated channel 2
VGNC:27396
505569
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chloride voltage-gated channel 2
Mouse
Dog
chloride voltage-gated channel 2
Horse
chloride voltage-gated channel 2
Cow
chloride voltage-gated channel 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (88)
1 – 10 of 88
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.819
Data Source:  STRINGDB
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
Score:  0.815
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.805
Data Source:  STRINGDB
EFHC1
Tbio
Novelty:  0.01722469
Score:  0.8
Data Source:  STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.78
Data Source:  STRINGDB
ANO1
Tclin
Family:  IC
Novelty:  0.00143722
Score:  0.777
Data Source:  STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.746
Data Source:  STRINGDB
HEPACAM
Tbio
Novelty:  0.01528258
Score:  0.737
Data Source:  STRINGDB
PRIM2
Tbio
Family:  Enzyme
Novelty:  0.05145449
Score:  0.712
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.711
Data Source:  STRINGDB
Publication Statistics
PubMed Score  128.17

PubMed score by year
PubTator Score  177.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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