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Tbio
USP11
Ubiquitin carboxyl-terminal hydrolase 11

Protein Summary
Description
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Protein ubiquitination controls many intrace ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218348
  • ENSP00000218348
  • ENSG00000102226

Symbol
  • UHX1
  • UHX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
kinase perturbation
0.76
protein domain
0.73
disease perturbation
0.68
interacting protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (119)
1 – 10 of 119
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.9927641
p_ni: 0.0072359
Score: 0.839
Data Source: BioPlex,STRINGDB
UBE2W
Tbio
Novelty: 0.07255713
p_int: 0.888626029
p_ni: 0.111373971
Data Source: BioPlex
IFT43
Tbio
Novelty: 0.00478274
p_int: 0.867465606
p_ni: 0.132534394
Score: 0.71
Data Source: BioPlex,STRINGDB
TRUB1
Tbio
Family: Enzyme
Novelty: 0.07013834
p_int: 0.860875108
p_ni: 0.139124892
Score: 0.862
Data Source: BioPlex,STRINGDB
MIER2
Tbio
Novelty: 0.85226416
p_int: 0.860082376
p_ni: 0.139917624
Score: 0.18
Data Source: BioPlex,STRINGDB
VGLL4
Tbio
Novelty: 0.03384856
p_int: 0.85820749
p_ni: 0.14179251
Score: 0.465
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
Score: 0.903
Data Source: STRINGDB
NFKBIA
Tchem
Novelty: 0.00022873
Score: 0.903
Data Source: Reactome,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
Score: 0.903
Data Source: STRINGDB
CCT7
Tbio
Novelty: 0.02247038
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.89

PubMed score by year
PubTator Score  17.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer