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Tbio
APLP1
Amyloid-like protein 1

Protein Summary
Description
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221891
  • ENSP00000221891
  • ENSG00000105290

Symbol
  • APLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.82
PubMedID
0.82
gene perturbation
0.76
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.44   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.44   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (88)
1 – 10 of 88
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.999999998
p_ni:  2e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.999992337
p_ni:  0.000007141
p_wrong:  5.21e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
APBB3
Tbio
Novelty:  0.15864948
p_int:  0.999980979
p_ni:  0.000018897
p_wrong:  1.25e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
APBA2
Tbio
Novelty:  0.01654185
Score:  0.79
Data Source:  STRINGDB
APBA1
Tbio
Novelty:  0.01126648
Score:  0.787
Data Source:  STRINGDB
APBA3
Tbio
Novelty:  0.05059532
Score:  0.779
Data Source:  STRINGDB
BACE1
Tchem
Family:  Enzyme
Novelty:  0.00042175
Score:  0.732
Data Source:  STRINGDB
CLIP3
Tbio
Novelty:  0.08151142
Score:  0.661
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.649
Data Source:  STRINGDB
SPON1
Tbio
Novelty:  0.01071398
Score:  0.633
Data Source:  STRINGDB
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
vitamin D measurement
2
1
2
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
vitamin D measurement
2
53.7
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor like protein 1
VGNC:7469
100614338
Macaque
amyloid beta precursor like protein 1
711258
Mouse
MGI:88046
11803
Rat
RGD:69257
502317
Dog
amyloid beta precursor like protein 1
VGNC:37988
476478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor like protein 1
Macaque
amyloid beta precursor like protein 1
Mouse
Rat
Dog
amyloid beta precursor like protein 1
Publication Statistics
PubMed Score 79.44
PubMed score by year
PubTator Score 65.89
PubTator score by year