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Tchem
STAT5B
Signal transducer and activator of transcription 5B

Protein Classes
Protein Summary
Description
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293328
  • ENSP00000293328
  • ENSG00000173757

Symbol
  • STAT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.99
hub protein
0.98
interacting protein
0.98
biological term
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1210.33   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 832   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1210.33   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 832   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
89.3
heel bone mineral density
1
1
1
66.6
1
1
0
1
34.5
1
1
0
1
32.8
childhood onset asthma
1
1
0
1.2
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
89.3
heel bone mineral density
1
66.6
0
1
34.5
0
1
32.8
childhood onset asthma
0
1.2
21.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:103035
20851
Rat
RGD:3774
25126
Cow
signal transducer and activator of transcription 5B
VGNC:35373
282376
Pig
signal transducer and activator of transcription 5B
397340
Chicken
signal transducer and activator of transcription 5B
CGNC:49373
395556
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
signal transducer and activator of transcription 5B
Pig
signal transducer and activator of transcription 5B
Chicken
signal transducer and activator of transcription 5B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51692-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (115)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Reactome
Erythropoietin activates STAT5
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Erythropoietin activates STAT5
Gene Ontology Terms (65)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (366)
1 – 10 of 366
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.949
Data Source: BioPlex,Reactome,STRINGDB
ADAM32
Tdark
Family: Enzyme
Novelty: 0.36071191
p_int: 0.999224247
p_ni: 0.000775753
Score: 0.187
Data Source: BioPlex,STRINGDB
TRMO
Tbio
Novelty: 0.18313621
p_int: 0.995094101
p_ni: 0.003802384
p_wrong: 0.001103516
Score: 0.416
Data Source: BioPlex,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.999
Data Source: Reactome,STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.997
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.996
Data Source: Reactome,STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.991
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.99
Data Source: STRINGDB
PRLR
Tbio
Novelty: 0.00161982
Score: 0.988
Data Source: Reactome,STRINGDB
IL2RA
Tclin
Novelty: 0.0007607
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  1210.33

PubMed score by year
PubTator Score  248.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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