Tbio ARSE Arylsulfatase E

Protein Summary

Description

May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• P51690
• Q53FT2
• Q53FU8
• ASE

Gene Name

• ARSE

Ensembl ID

• ENST00000381134
• ENSP00000370526
• ENSG00000157399

Symbol

• ASE
• CDPX
• CDPX1
• CDPXR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.76
cellular component	0.69
protein domain	0.58
tissue sample	0.58
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Arylsulfatase E

DTO Classes

Protein / Enzyme / Hydrolase / Arylsulfatase E

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 830.06   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 830.06   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0