Protein Summary
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
- ENST00000381154
- ENSP00000370546
- ENSG00000006756
- ASD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.76 | ||
cell type or tissue | 0.7 | ||
tissue sample | 0.63 | ||
microRNA | 0.62 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 147.17 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 151 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 147.17 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 151 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (26)
ARSE
Family: Enzyme
Novelty: 0.00151862
p_int: 0.999999858
p_wrong: 1.42e-7
Score: 0.904
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (8)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 2 | 6 | 81.8 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 77.1 | |||||
body height | 2 | 1 | 2 | 52.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 81.8 | |||||
low density lipoprotein cholesterol measurement | 1 | 77.1 | |||||
body height | 2 | 52.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | arylsulfatase D | 704070 | ||||||
Dog | arylsulfatase D | VGNC:53702 | 491718 | |||||
Platypus | arylsulfatase D-like | 100083853 | ||||||
Chicken | arylsulfatase family, member H | CGNC:49125 | 378798 | |||||
Anole lizard | arylsulfatase H | 100554941 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | arylsulfatase D | |||||
Dog | arylsulfatase D | |||||
Platypus | arylsulfatase D-like | |||||
Chicken | arylsulfatase family, member H | |||||
Anole lizard | arylsulfatase H | |||||
Publication Statistics
PubMed Score 147.17
PubMed score by year
PubTator Score 82.44
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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