Tbio SGSH N-sulphoglucosamine sulphohydrolase

Protein Summary

Description

Catalyzes a step in lysosomal heparan sulfate degradation. This gene encodes the enzyme sulfamidase; one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with the lysosomal storage disease mucopolysaccaridosis IIIA, also known as Sanfilippo syndrome A, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jun 2017]

Uniprot Accession IDs

• P51688
• A8K5E2

Gene Name

• SGSH

Ensembl ID

• ENST00000326317
• ENSP00000314606
• ENSG00000181523

Symbol

• HSS
• HSS
• SFMD
• MPS3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.92
histone modification site profile	0.86
kinase perturbation	0.76
virus perturbation	0.76
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Hydrolase / N-sulphoglucosamine Sulphohydrolase

DTO Classes

Protein / Enzyme / Hydrolase / N-sulphoglucosamine Sulphohydrolase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.71   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.71   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0