Tchem CCR9 C-C chemokine receptor type 9

Protein Summary

Description

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P51686
• Q4VBM3
• Q549E0
• Q9UQQ6
• C-C CKR-9

Gene Name

• CCR9

Ensembl ID

• ENST00000355983
• ENSP00000348260
• ENSG00000173585
• ENST00000357632
• ENSP00000350256
• ENST00000395963
• ENSP00000379292

Symbol

• GPR28
• GPR28
• CDw199
• GPR-9-6
• CC-CKR-9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.72
disease perturbation	0.68
cell type or tissue	0.63
protein domain	0.58
gene perturbation	0.56

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.34   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 599   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.34   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 117

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0