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Tchem
CCR9
C-C chemokine receptor type 9

Protein Summary
Description
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355983
  • ENSP00000348260
  • ENSG00000173585
  • ENST00000357632
  • ENSP00000350256
  • ENST00000395963
  • ENSP00000379292

Symbol
  • GPR28
  • GPR28
  • CDw199
  • GPR-9-6
  • CC-CKR-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.72
disease perturbation
0.68
cell type or tissue
0.63
protein domain
0.58
gene perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 599   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
81.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 9
VGNC:8829
470808
Macaque
C-C motif chemokine receptor 9
713934
Mouse
MGI:1341902
12769
Rat
RGD:628750
282832
Dog
C-C motif chemokine receptor 9
VGNC:38917
484793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 9
Macaque
C-C motif chemokine receptor 9
Mouse
Rat
Dog
C-C motif chemokine receptor 9
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51686-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (305)
1 – 10 of 305
CCL25
Tbio
Novelty: 0.00824289
Score: 0.996
Data Source: Reactome,STRINGDB
CCL28
Tbio
Novelty: 0.00513161
Score: 0.963
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.959
Data Source: STRINGDB
CCL19
Tbio
Novelty: 0.00169711
Score: 0.957
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.956
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.95
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.947
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.947
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.945
Data Source: STRINGDB
CCL27
Tbio
Novelty: 0.00163457
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  142.37

PubMed score by year
PubTator Score  118.66

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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