Tchem CCR8 C-C chemokine receptor type 8

Protein Summary

Description

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51685
• B2RC64
• Q3KNQ8
• Q3KNR3
• Q9BYX5
• C-C CKR-8

Gene Name

• CCR8

Ensembl ID

• ENST00000326306
• ENSP00000326432
• ENSG00000179934

Symbol

• CKRL1
• CMKBR8
• CMKBRL2
• CY6
• TER1
• CCR-8
• CKRL1
• CDw198
• CMKBR8
• GPRCY6
• CMKBRL2
• CC-CKR-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
protein domain	0.58
tissue	0.58
molecular function	0.49
biological term	0.47

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.06   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 520   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.06   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0