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Tclin
CCR5
C-C chemokine receptor type 5

Protein Summary
Description
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
molecular function
0.94
PubMedID
0.94
biological process
0.84
biological term
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4662.06   (req: < 5)
Gene RIFs: 655   (req: <= 3)
Antibodies: 1618   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4662.06   (req: >= 5)
Gene RIFs: 655   (req: > 3)
Antibodies: 1618   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1169
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
maraviroc
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
85.9
granulocyte percentage of myeloid white cells
1
1
1
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
85.9
granulocyte percentage of myeloid white cells
1
17.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 5
VGNC:11366
450128
Mouse
MGI:107182
12774
Rat
RGD:620596
117029
Dog
C-C motif chemokine receptor 5
484789
Cow
C-C motif chemokine receptor 5
497017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 5
Mouse
Rat
Dog
C-C motif chemokine receptor 5
Cow
C-C motif chemokine receptor 5
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Binding and entry of HIV virion (R-HSA-173107)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and entry of HIV virion
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Binding and entry of HIV virion
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (36)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (604)
1 – 10 of 604
CCL5
Tchem
Novelty: 0.00032607
Score: 0.999
Data Source: Reactome,STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.997
Data Source: Reactome,STRINGDB
CCL3L1
Tbio
Novelty: 0.01124082
Score: 0.993
Data Source: STRINGDB
CCL3
Tbio
Novelty: 0.00049216
Score: 0.986
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.984
Data Source: STRINGDB
CCL11
Tbio
Novelty: 0.00086805
Score: 0.982
Data Source: STRINGDB
CCL4L1
Tbio
Novelty: 0.00164787
Score: 0.98
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.979
Data Source: STRINGDB
CCL13
Tbio
Novelty: 0.00593527
Score: 0.979
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  4662.06

PubMed score by year
PubTator Score  2691.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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