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Tclin
CCR4
C-C chemokine receptor type 4

Protein Summary
Description
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330953
  • ENSP00000332659
  • ENSG00000183813

Symbol
  • CMKBR4
  • CKR4
  • K5-5
  • CD194
  • CMKBR4
  • ChemR13
  • CC-CKR-4
  • HGCN:14099
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
phenotype
0.68
biological term
0.66
tissue
0.65
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.38   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 696   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.38   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 696   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
4.5
1
1
0
1.1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
4.5
0
1.1
4.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 4
VGNC:11365
470781
Macaque
C-C motif chemokine receptor 4
705457
Mouse
MGI:107824
12773
Rat
RGD:620594
171054
Dog
C-C motif chemokine receptor 4
VGNC:38913
403541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 4
Macaque
C-C motif chemokine receptor 4
Mouse
Rat
Dog
C-C motif chemokine receptor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51679-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (271)
1 – 10 of 271
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.982
Data Source: STRINGDB
CCL17
Tbio
Novelty: 0.00160208
Score: 0.977
Data Source: STRINGDB
CCL22
Tbio
Novelty: 0.00245992
Score: 0.973
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.968
Data Source: Reactome,STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.942
Data Source: STRINGDB
CCL4L1
Tbio
Novelty: 0.00164787
Score: 0.938
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.937
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.928
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.926
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.38

PubMed score by year
PubTator Score  431.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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