Tchem CCR3 C-C chemokine receptor type 3

Protein Summary

Description

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P51677
• B3KVQ1
• F5GWL6
• Q15748
• Q2YDB9
• Q86WD2
• Q8TDP6
• Q9ULY8
• C-C CKR-3

Gene Name

• CCR3

Ensembl ID

• ENST00000357422
• ENSP00000350003
• ENSG00000183625
• ENST00000395940
• ENSP00000379271
• ENST00000395942
• ENSP00000379273
• ENST00000545097
• ENSP00000441600

Symbol

• CMKBR3
• CKR3
• CD193
• CMKBR3
• CC-CKR-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	1
co-expressed gene	0.94
gene perturbation	0.76
biological term	0.73
disease	0.71

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.12   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 731   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.12   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 695

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0