Protein Summary
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
- ENST00000305869
- ENSP00000302234
- ENSG00000172156
- SCYA11
- SCYA11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
biological process | 0.94 | ||
disease | 0.88 | ||
biological term | 0.87 | ||
chemical | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1173.65 (req: < 5)
Gene RIFs: 118 (req: <= 3)
Antibodies: 361 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1173.65 (req: >= 5)
Gene RIFs: 118 (req: > 3)
Antibodies: 361 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (191)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (15)
Reactome (4)
KEGG (5)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (44)
Functions (5)
Components (3)
Processes (36)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 80.3 | |||||
3 | 2 | 0 | 1.2 | 79 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 77.4 | |||||
monocyte count | 1 | 1 | 1 | 76.5 | |||||
monocyte chemotactic protein 1 measurement | 1 | 1 | 1 | 10.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 80.3 | |||||
0 | 1.2 | 79 | |||||
monocyte percentage of leukocytes | 2 | 77.4 | |||||
monocyte count | 1 | 76.5 | |||||
monocyte chemotactic protein 1 measurement | 1 | 10.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 11 | 574218 | ||||||
Mouse | MGI:103576 | 20292 | ||||||
Rat | RGD:3644 | 29397 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 11 | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 1173.65
PubMed score by year
PubTator Score 583.38
PubTator score by year
Related Publications
Text Mined References (182)
GeneRif Annotations (118)
Items per page:
0 of 0
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