Tbio CCL11 Eotaxin

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Eotaxin

DTO Classes

Protein / Signaling / Chemokine / Eotaxin

Protein Summary

Description

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P51671
• P50877
• Q92490
• Q92491

Gene Name

• CCL11

Ensembl ID

• ENST00000305869
• ENSP00000302234
• ENSG00000172156

Symbol

• SCYA11
• SCYA11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
biological process	0.94
disease	0.88
biological term	0.87
chemical	0.82

Related Tools

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GlyGen

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.26   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 361   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.26   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	C-C motif chemokine ligand 11		574218
Mouse	chemokine (C-C motif) ligand 11	MGI:103576	20292
Rat	C-C motif chemokine ligand 11	RGD:3644	29397

Species	Name	OMA	EggNOG	Inparanoid
Macaque	C-C motif chemokine ligand 11
Mouse	chemokine (C-C motif) ligand 11
Rat	C-C motif chemokine ligand 11

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51671-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (15)

Reactome (4)

KEGG (5)

PathwayCommons (3)

WikiPathways (3)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (44)

Functions (5)

Components (3)

Processes (36)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
CCR3 chemokine receptor binding	Inferred from Direct Assay (IDA)	CAFA
chemokine activity	Inferred from Direct Assay (IDA)	UniProtKB
protein dimerization activity	Inferred from Direct Assay (IDA)	CAFA
receptor ligand activity	Inferred from Direct Assay (IDA)	CAFA
CCR chemokine receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (191)

Explore Interacting Targets

1 – 10 of 191

• See Interactions on String-DB

CCR3

Tchem

Family: GPCR

Novelty: 0.00197059

Score: 0.999

Data Source: STRINGDB

CXCL10

Tchem

Novelty: 0.00040194

Score: 0.988

Data Source: STRINGDB

CCR5

Tclin

Family: GPCR

Novelty: 0.00022549

Score: 0.982

Data Source: STRINGDB

CXCR3

Tchem

Family: GPCR

Novelty: 0.00100538

Score: 0.975

Data Source: STRINGDB

CXCL12

Tbio

Novelty: 0.00026817

Score: 0.969

Data Source: STRINGDB

STAT6

Tchem

Family: TF

Novelty: 0.00096732

Score: 0.962

Data Source: STRINGDB

CCR2

Tchem

Family: GPCR

Novelty: 0.0006525

Score: 0.958

Data Source: STRINGDB

CXCR4

Tclin

Family: GPCR

Novelty: 0.0002811

Score: 0.951

Data Source: STRINGDB

IL4

Tbio

Novelty: 0.00005852

Score: 0.946

Data Source: STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00011808

Score: 0.936

Data Source: STRINGDB

Publication Statistics

PubMed Score  1146.26

PubMed score by year

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PubTator Score  583.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Inflammatory response
Polymorphism
Reference proteome

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
immune system phenotype