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Tbio
UBE2D1
Ubiquitin-conjugating enzyme E2 D1

Protein Classes
Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373910
  • ENSP00000363019
  • ENSG00000072401

Symbol
  • SFT
  • UBC5A
  • UBCH5
  • UBCH5A
  • SFT
  • UBCH5
  • UBC4/5
  • UBCH5A
  • E2(17)KB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.95
molecular function
0.91
virus perturbation
0.88
microRNA
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.99   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.99   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 D1
VGNC:7272
745141
Macaque
ubiquitin conjugating enzyme E2 D1
701491
Mouse
MGI:2384911
216080
Rat
RGD:1307886
361831
Dog
ubiquitin conjugating enzyme E2 D1
VGNC:48050
608578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 D1
Macaque
ubiquitin conjugating enzyme E2 D1
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 D1
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (84)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 74
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Protein-Protein Interactions (625)
1 – 10 of 625
URGCP
Tbio
Novelty: 0.05171079
p_int: 0.99999996
p_ni: 4e-8
Data Source: BioPlex
RNF10
Tbio
Novelty: 0.09086567
p_int: 0.999999235
p_ni: 7.64e-7
p_wrong: 1e-9
Score: 0.247
Data Source: BioPlex,STRINGDB
TOPORS
Tbio
Family: Enzyme
Novelty: 0.03910082
p_int: 0.999997826
p_ni: 0.000002174
Score: 0.559
Data Source: BioPlex,STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
p_int: 0.999993437
p_ni: 0.000006563
Score: 0.978
Data Source: BioPlex,STRINGDB
RNF25
Tbio
Family: Enzyme
Novelty: 0.08945219
p_int: 0.999973948
p_ni: 0.000026049
p_wrong: 3e-9
Score: 0.962
Data Source: BioPlex,STRINGDB
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.98963875
p_ni: 0.010361244
p_wrong: 6e-9
Data Source: BioPlex
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00149368
p_int: 0.988758633
p_ni: 0.011241362
p_wrong: 5e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
HECTD1
Tbio
Family: Enzyme
Novelty: 0.28016112
p_int: 0.987775679
p_ni: 0.012224321
Score: 0.924
Data Source: BioPlex,STRINGDB
RNF114
Tbio
Family: Enzyme
Novelty: 0.06758257
p_int: 0.987647767
p_ni: 0.01235222
p_wrong: 1.3e-8
Score: 0.939
Data Source: BioPlex,STRINGDB
OTUB1
Tbio
Family: Enzyme
Novelty: 0.00536726
p_int: 0.902285357
p_ni: 0.097714643
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  85.99

PubMed score by year
PubTator Score  64.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer