Tbio HSD17B4 Peroxisomal multifunctional enzyme type 2

Protein Summary

Description

Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P51659
• B4DNV1
• B4DVS5
• E9PB82
• F5HE57
• MFE-2

Gene Name

• HSD17B4

Ensembl ID

• ENST00000256216
• ENSP00000256216
• ENSG00000133835
• ENST00000414835
• ENSP00000411960
• ENST00000504811
• ENSP00000420914
• ENST00000510025
• ENSP00000424940
• ENST00000515320
• ENSP00000424613

Symbol

• EDH17B4
• SDR8C1
• DBP
• MFE-2
• MPF-2
• PRLTS1
• SDR8C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.99
protein domain	0.92
kinase perturbation	0.91
protein complex	0.82

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.47   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 366   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.47   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	hydroxysteroid 17-beta dehydrogenase 4	VGNC:13510	462019
Macaque	hydroxysteroid 17-beta dehydrogenase 4		698369
Mouse	hydroxysteroid (17-beta) dehydrogenase 4	MGI:105089	15488
Rat	hydroxysteroid (17-beta) dehydrogenase 4	RGD:621806	79244
Dog	hydroxysteroid 17-beta dehydrogenase 4	VGNC:41807	474630

Species	Name	OMA	EggNOG	Inparanoid
Chimp	hydroxysteroid 17-beta dehydrogenase 4
Macaque	hydroxysteroid 17-beta dehydrogenase 4
Mouse	hydroxysteroid (17-beta) dehydrogenase 4
Rat	hydroxysteroid (17-beta) dehydrogenase 4
Dog	hydroxysteroid 17-beta dehydrogenase 4

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51659-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (30)

Reactome (15)

KEGG (5)

UniProt (1)

WikiPathways (9)

Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

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Find Similar Targets

Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-oxidation of pristanoyl-CoA	9 targets	R-HSA-389887
Reactome	Beta-oxidation of very long chain fatty acids	11 targets	R-HSA-390247
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Beta-oxidation of pristanoyl-CoA	9 targets	R-HSA-389887
Beta-oxidation of very long chain fatty acids	11 targets	R-HSA-390247
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Fatty acid metabolism	176 targets	R-HSA-8978868
Metabolism	2112 targets	R-HSA-1430728

Gene Ontology Terms (24)

Functions (7)

Components (5)

Processes (12)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
17-beta-hydroxysteroid dehydrogenase (NAD+) activity	Inferred from Direct Assay (IDA)	UniProtKB
3-hydroxyacyl-CoA dehydrogenase activity	Inferred from Direct Assay (IDA)	UniProtKB
long-chain-enoyl-CoA hydratase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity	Traceable Author Statement (TAS)	Reactome
isomerase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (179)

Explore Interacting Targets

1 – 10 of 179

• See Interactions on String-DB

IKZF1

Tbio

Family: TF

Novelty: 0.0016117

p_int: 0.907932021

p_ni: 0.092067979

Score: 0.221

Data Source: BioPlex,STRINGDB

ACAA1

Tbio

Family: Enzyme

Novelty: 0.00710465

Score: 0.998

Data Source: STRINGDB

SCP2

Tchem

Novelty: 0.00183736

Score: 0.995

Data Source: STRINGDB

ACOX3

Tbio

Family: Enzyme

Novelty: 0.04077258

Score: 0.99

Data Source: STRINGDB

ACOX1

Tbio

Family: Enzyme

Novelty: 0.00473427

Score: 0.989

Data Source: STRINGDB

CRAT

Tbio

Family: Enzyme

Novelty: 0.01242609

Score: 0.989

Data Source: STRINGDB

ECH1

Tbio

Family: Enzyme

Novelty: 0.02471875

Score: 0.987

Data Source: STRINGDB

ACOX2

Tbio

Family: Enzyme

Novelty: 0.02942359

Score: 0.984

Data Source: STRINGDB

EHHADH

Tbio

Novelty: 0.00878193

Score: 0.984

Data Source: STRINGDB

CAT

Tbio

Family: Enzyme

Novelty: 0.00181888

Score: 0.979

Data Source: STRINGDB

Publication Statistics

PubMed Score  188.47

PubMed score by year

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PubTator Score  73.65

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Complete proteome
Deafness
Direct protein sequencing
Disease mutation
Fatty acid metabolism
Isomerase
Lipid metabolism

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
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digestive/alimentary phenotype
endocrine/exocrine gland phenotype
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hearing/vestibular/ear phenotype
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