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Tbio
HSD17B4
Peroxisomal multifunctional enzyme type 2

Protein Summary
Description
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256216
  • ENSP00000256216
  • ENSG00000133835
  • ENST00000414835
  • ENSP00000411960
  • ENST00000504811
  • ENSP00000420914
  • ENST00000510025
  • ENSP00000424940
  • ENST00000515320
  • ENSP00000424613

Symbol
  • EDH17B4
  • SDR8C1
  • DBP
  • MFE-2
  • MPF-2
  • PRLTS1
  • SDR8C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein domain
0.92
kinase perturbation
0.91
protein complex
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.15   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.15   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Bile acid and bile salt metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Bile acid and bile salt metabolism
Fatty acid metabolism
Metabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (179)
1 – 10 of 179
IKZF1
Tbio
Family: TF
Novelty: 0.00201134
p_int: 0.907932021
p_ni: 0.092067979
Score: 0.221
Data Source: BioPlex,STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00482727
Score: 0.998
Data Source: STRINGDB
SCP2
Tchem
Novelty: 0.00215179
Score: 0.995
Data Source: STRINGDB
ACOX3
Tbio
Family: Enzyme
Novelty: 0.07064102
Score: 0.99
Data Source: STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00626693
Score: 0.989
Data Source: STRINGDB
CRAT
Tbio
Family: Enzyme
Novelty: 0.01538925
Score: 0.989
Data Source: STRINGDB
ECH1
Tbio
Family: Enzyme
Novelty: 0.04455822
Score: 0.987
Data Source: STRINGDB
ACOX2
Tbio
Family: Enzyme
Novelty: 0.05104162
Score: 0.984
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00763197
Score: 0.984
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00022628
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.15

PubMed score by year
PubTator Score  73.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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