HSD17B4
Peroxisomal multifunctional enzyme type 2
Protein Summary
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
- ENST00000256216
- ENSP00000256216
- ENSG00000133835
- ENST00000414835
- ENSP00000411960
- ENST00000504811
- ENSP00000420914
- ENST00000510025
- ENSP00000424940
- ENST00000515320
- ENSP00000424613
- EDH17B4
- SDR8C1
- DBP
- MFE-2
- MPF-2
- PRLTS1
- SDR8C1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.99 | ||
protein domain | 0.92 | ||
kinase perturbation | 0.91 | ||
protein complex | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.34 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 366 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.34 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 366 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (179)
IKZF1
Family: TF
Novelty: 0.0016117
p_int: 0.907932021
p_ni: 0.092067979
Score: 0.221
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (15)
KEGG (5)
UniProt (1)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-oxidation of pristanoyl-CoA | ||||
Reactome | Beta-oxidation of very long chain fatty acids | ||||
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-oxidation of pristanoyl-CoA | ||||
Beta-oxidation of very long chain fatty acids | ||||
Bile acid and bile salt metabolism | ||||
Fatty acid metabolism | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (7)
Components (5)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 5 | 11 | 15 | 94.9 | |||||
waist-hip ratio | 4 | 11 | 13 | 94.9 | |||||
hip circumference | 1 | 9 | 9 | 92.1 | |||||
lymphocyte count | 2 | 2 | 2 | 92 | |||||
triglyceride measurement | 4 | 2 | 4 | 84.7 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 15 | 94.9 | |||||
waist-hip ratio | 13 | 94.9 | |||||
hip circumference | 9 | 92.1 | |||||
lymphocyte count | 2 | 92 | |||||
triglyceride measurement | 4 | 84.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 4 | VGNC:13510 | 462019 | |||||
Macaque | hydroxysteroid 17-beta dehydrogenase 4 | 698369 | ||||||
Mouse | MGI:105089 | 15488 | ||||||
Rat | RGD:621806 | 79244 | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 4 | VGNC:41807 | 474630 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Macaque | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Publication Statistics
PubMed Score 195.34
PubMed score by year
PubTator Score 73.65
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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