HSD17B4
Peroxisomal multifunctional enzyme type 2
Protein Summary
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
- ENST00000256216
- ENSP00000256216
- ENSG00000133835
- ENST00000414835
- ENSP00000411960
- ENST00000504811
- ENSP00000420914
- ENST00000510025
- ENSP00000424940
- ENST00000515320
- ENSP00000424613
- EDH17B4
- SDR8C1
- DBP
- MFE-2
- MPF-2
- PRLTS1
- SDR8C1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.99 | ||
protein domain | 0.92 | ||
kinase perturbation | 0.91 | ||
protein complex | 0.82 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.47 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 366 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.47 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 366 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 4 | VGNC:13510 | 462019 | |||||
Macaque | hydroxysteroid 17-beta dehydrogenase 4 | 698369 | ||||||
Mouse | MGI:105089 | 15488 | ||||||
Rat | RGD:621806 | 79244 | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 4 | VGNC:41807 | 474630 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Macaque | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 4 | |||||
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (15)
KEGG (5)
UniProt (1)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-oxidation of pristanoyl-CoA | ||||
Reactome | Beta-oxidation of very long chain fatty acids | ||||
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-oxidation of pristanoyl-CoA | ||||
Beta-oxidation of very long chain fatty acids | ||||
Bile acid and bile salt metabolism | ||||
Fatty acid metabolism | ||||
Metabolism | ||||
Gene Ontology Terms (24)
Functions (7)
Components (5)
Processes (12)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (179)
1 – 10 of 179
IKZF1
Family: TF
Novelty: 0.0016117
p_int: 0.907932021
p_ni: 0.092067979
Score: 0.221
Data Source: BioPlex,STRINGDB
ACAA1
Family: Enzyme
Novelty: 0.00710465
Score: 0.998
Data Source: STRINGDB
SCP2
Novelty: 0.00183736
Score: 0.995
Data Source: STRINGDB
ACOX3
Family: Enzyme
Novelty: 0.04077258
Score: 0.99
Data Source: STRINGDB
ACOX1
Family: Enzyme
Novelty: 0.00473427
Score: 0.989
Data Source: STRINGDB
CRAT
Family: Enzyme
Novelty: 0.01242609
Score: 0.989
Data Source: STRINGDB
ECH1
Family: Enzyme
Novelty: 0.02471875
Score: 0.987
Data Source: STRINGDB
ACOX2
Family: Enzyme
Novelty: 0.02942359
Score: 0.984
Data Source: STRINGDB
EHHADH
Novelty: 0.00878193
Score: 0.984
Data Source: STRINGDB
CAT
Family: Enzyme
Novelty: 0.00181888
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score 188.47
PubMed score by year
PubTator Score 73.65
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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