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Tbio
GPC3
Glypican-3

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb pattern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370818
  • ENSP00000359854
  • ENSG00000147257
  • ENST00000394299
  • ENSP00000377836
  • ENST00000631057
  • ENSP00000486325

Symbol
  • OCI5
  • SGB
  • DGSX
  • MXR7
  • SDYS
  • SGBS
  • OCI-5
  • SGBS1
  • GTR2-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.98
PubMedID
0.89
biological term
0.85
small molecule perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.18   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 1325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.18   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 1325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (32)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Reactome
Defective B4GALT7 causes EDS, progeroid type
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
Gene Ontology Terms (41)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (292)
1 – 10 of 292
TRIM68
Tbio
Family: Enzyme
Novelty: 0.27820711
p_int: 0.999990096
p_ni: 0.000009904
Data Source: BioPlex
HADHA
Tbio
Novelty: 0.00234785
p_int: 0.999988857
p_ni: 0.000011143
Data Source: BioPlex
CAMKV
Tbio
Family: Kinase
Novelty: 0.02297481
p_int: 0.999978855
p_ni: 0.000021145
Score: 0.15
Data Source: BioPlex,STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.01573742
p_int: 0.999972365
p_ni: 0.000025588
p_wrong: 0.000002047
Data Source: BioPlex
PARP16
Tbio
Family: Enzyme
Novelty: 0.02664352
p_int: 0.999921321
p_ni: 0.000067727
p_wrong: 0.000010952
Data Source: BioPlex
ULBP1
Tbio
Novelty: 0.02190147
p_int: 0.999739799
p_ni: 0.000260201
Score: 0.189
Data Source: BioPlex,STRINGDB
GPR183
Tchem
Family: GPCR
Novelty: 0.021257
p_int: 0.999735258
p_ni: 0.000264724
p_wrong: 1.8e-8
Data Source: BioPlex
LRRTM4
Tbio
Novelty: 0.17645205
p_int: 0.999528347
p_ni: 0.000471652
p_wrong: 1e-9
Score: 0.333
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00466391
p_int: 0.999397747
p_ni: 0.000596169
p_wrong: 0.000006084
Data Source: BioPlex
ODAPH
Tbio
Novelty: 0.49135043
p_int: 0.998774298
p_ni: 0.00118123
p_wrong: 0.000044472
Data Source: BioPlex
Publication Statistics
PubMed Score  972.18

PubMed score by year
PubTator Score  535.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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