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Tbio
GPC3
Glypican-3

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb pattern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370818
  • ENSP00000359854
  • ENSG00000147257
  • ENST00000394299
  • ENSP00000377836
  • ENST00000631057
  • ENSP00000486325

Symbol
  • OCI5
  • SGB
  • DGSX
  • MXR7
  • SDYS
  • SGBS
  • OCI-5
  • SGBS1
  • GTR2-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.98
PubMedID
0.89
biological term
0.85
small molecule perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 922.38   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 1325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 922.38   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 1325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0