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Tbio
ALDH3A2
Fatty aldehyde dehydrogenase

Protein Summary
Description
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000176643
  • ENSP00000176643
  • ENSG00000072210
  • ENST00000339618
  • ENSP00000345774
  • ENST00000395575
  • ENSP00000378942
  • ENST00000579855
  • ENSP00000463637
  • ENST00000581518
  • ENSP00000461916

Symbol
  • ALDH10
  • FALDH
  • SLS
  • FALDH
  • ALDH10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.97
protein domain
0.92
histone modification site profile
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.08   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.08   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (160)
1 – 10 of 160
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.999563017
p_ni:  0.000436983
Data Source:  BioPlex
HOOK2
Tbio
Novelty:  0.03559628
p_int:  0.999148128
p_ni:  0.000851859
p_wrong:  1.3e-8
Data Source:  BioPlex
CIP2A
Tbio
Novelty:  0.00992381
p_int:  0.99783151
p_ni:  0.00216849
Data Source:  BioPlex
VPS8
Tbio
Novelty:  0.05178496
p_int:  0.994902604
p_ni:  0.005095739
p_wrong:  0.000001658
Score:  0.179
Data Source:  BioPlex,STRINGDB
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.99349831
p_ni:  0.00650169
Data Source:  BioPlex
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.989585346
p_ni:  0.010414654
Score:  0.216
Data Source:  BioPlex,STRINGDB
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.984725542
p_ni:  0.015274284
p_wrong:  1.74e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
p_int:  0.983650872
p_ni:  0.01632123
p_wrong:  0.000027898
Data Source:  BioPlex
IPO13
Tbio
Novelty:  0.01954093
p_int:  0.970779854
p_ni:  0.029220145
Score:  0.18
Data Source:  BioPlex,STRINGDB
INTS1
Tbio
Novelty:  0.17523407
p_int:  0.965882608
p_ni:  0.034117392
Score:  0.527
Data Source:  BioPlex,STRINGDB
Pathways (43)
Alpha-oxidation of phytanate (R-HSA-389599)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-oxidation of phytanate
Reactome
Class I peroxisomal membrane protein import
Reactome
Fatty acid metabolism
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Alpha-oxidation of phytanate
Class I peroxisomal membrane protein import
Fatty acid metabolism
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Metabolism
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
3
3
83.6
glomerular filtration rate
1
2
2
78.7
intraocular pressure measurement
1
2
2
52.3
1
1
1
51.4
mean platelet volume
1
1
1
5.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
83.6
glomerular filtration rate
2
78.7
intraocular pressure measurement
2
52.3
1
51.4
mean platelet volume
1
5.1
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member A2
VGNC:6331
454505
Macaque
aldehyde dehydrogenase 3 family member A2
703661
Mouse
MGI:1353452
11671
Rat
RGD:61866
65183
Horse
aldehyde dehydrogenase 3 family member A2
VGNC:15235
100073165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member A2
Macaque
aldehyde dehydrogenase 3 family member A2
Mouse
Rat
Horse
aldehyde dehydrogenase 3 family member A2
Publication Statistics
PubMed Score 179.08
PubMed score by year
PubTator Score 108.62
PubTator score by year