Tbio CAV2 Caveolin-2

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P51636
• A4D0U2
• Q9UGM7

Gene Name

• CAV2

Ensembl ID

• ENST00000222693
• ENSP00000222693
• ENSG00000105971
• ENST00000343213
• ENSP00000345679

Symbol

• CAV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
PubMedID	0.95
biological process	0.86
ligand (protein) perturbation	0.83
small molecule perturbation	0.82

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Caveolin-2

Protein / Structural Protein / Caveolin-2

Protein / Membrane Traffic Protein / Caveolin-2

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.64   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 372   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.64   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0