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Tbio
HCFC1
Host cell factor 1

Protein Summary
Description
Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310441
  • ENSP00000309555
  • ENSG00000172534

Symbol
  • HCF1
  • HFC1
  • CFF
  • HCF
  • HCF1
  • HFC1
  • MRX3
  • VCAF
  • HCF-1
  • PPP1R89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
molecular function
0.91
biological process
0.85
cellular component
0.8
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.14   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.14   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
77.6
3
3
0
1.6
77.2
neutrophil percentage of leukocytes
1
1
1
75.5
lymphocyte percentage of leukocytes
1
1
1
74.4
albumin:globulin ratio measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77.6
0
1.6
77.2
neutrophil percentage of leukocytes
1
75.5
lymphocyte percentage of leukocytes
1
74.4
albumin:globulin ratio measurement
1
36.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
host cell factor C1
VGNC:12398
465933
Mouse
MGI:105942
15161
Rat
RGD:1563804
363519
Dog
host cell factor C1
VGNC:41615
492246
Horse
host cell factor C1
VGNC:18707
100058080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
host cell factor C1
Mouse
Rat
Dog
host cell factor C1
Horse
host cell factor C1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51610-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (187)
1 – 10 of 187
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.99931263
p_ni:  0.00068737
Score:  0.752
Data Source:  BioPlex,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.999301829
p_ni:  0.000698172
Score:  0.241
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.99682577
p_ni:  0.003174231
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
p_int:  0.992460217
p_ni:  0.007539783
Score:  0.854
Data Source:  BioPlex,STRINGDB
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
p_int:  0.98662303
p_ni:  0.01337697
Score:  0.87
Data Source:  BioPlex,STRINGDB
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.975211488
p_ni:  0.024788512
Score:  0.957
Data Source:  BioPlex,STRINGDB
DDAH2
Tbio
Family:  Enzyme
Novelty:  0.00355931
p_int:  0.972458567
p_ni:  0.027541433
Score:  0.228
Data Source:  BioPlex,STRINGDB
SENP5
Tbio
Family:  Enzyme
Novelty:  0.0510532
p_int:  0.968005444
p_ni:  0.031994556
Data Source:  BioPlex
HCFC1R1
Tbio
Novelty:  2.97633658
p_int:  0.967319043
p_ni:  0.032680957
Score:  0.379
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.873293989
p_ni:  0.126706011
Score:  0.212
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  241.14

PubMed score by year
PubTator Score  2434.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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