Tchem MECP2 Methyl-CpG-binding protein 2

Protein Summary

Description

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P51608
• O15233
• Q6QHH9
• Q7Z384
• MeCp-2 protein

Gene Name

• MECP2

Ensembl ID

• ENST00000303391
• ENSP00000301948
• ENSG00000169057
• ENST00000453960
• ENSP00000395535

Symbol

• RS
• RTS
• RTT
• PPMX
• MRX16
• MRX79
• MRXSL
• AUTSX3
• MRXS13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.93
biological term	0.8
microRNA	0.79
phenotype	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Methyl-cpg-binding Protein 2

Protein / Nucleic Acid Binding / Nuclease / Methyl-cpg-binding Protein 2

DTO Classes

Protein / Epigenetic Regulator / Reader / Methyl-cpg-binding Domain / Methyl-cpg-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2410.55   (req: < 5)

Gene RIFs: 544   (req: <= 3)

Antibodies: 780   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2410.55   (req: >= 5)

Gene RIFs: 544   (req: > 3)

Antibodies: 780   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0