Protein Summary
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
- ENST00000371204
- ENSP00000360247
- ENSG00000134716
- CPJ2
- CYPIIJ2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.88 | ||
molecular function | 0.81 | ||
histone modification site profile | 0.78 | ||
biological term | 0.7 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.51 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 308 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.51 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 308 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (6)
Protein-Protein Interactions (95)
MINDY2
Novelty: 0.46783751
p_int: 0.999999771
p_ni: 1.24e-7
p_wrong: 1.05e-7
Score: 0.252
Data Source: BioPlex,STRINGDB
TIPIN
Novelty: 0.03919376
p_int: 0.999996851
p_ni: 0.000002839
p_wrong: 3.1e-7
Data Source: BioPlex
PDE4DIP
Novelty: 0.03414104
p_int: 0.999696229
p_ni: 0.000264254
p_wrong: 0.000039516
Data Source: BioPlex
USP25
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999382772
p_ni: 0.000617228
Data Source: BioPlex
VPS28
Novelty: 0.02927315
p_int: 0.999017469
p_ni: 0.000970666
p_wrong: 0.000011865
Data Source: BioPlex
NELFE
Novelty: 0.02136256
p_int: 0.997102325
p_ni: 0.00289629
p_wrong: 0.000001385
Data Source: BioPlex
Nearest Tclin Targets (8)
Upstream (4)
Downstream (4)
1 – 4 of 4
Pathways (24)
Reactome (10)
KEGG (6)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Fatty acid metabolism | ||||
Fatty acids | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (10)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 1 | 0 | 7.7 | 13.4 | ||||
antisocial behaviour measurement | 1 | 1 | 1 | 11.3 | |||||
1 | 1 | 1 | 11.3 | ||||||
substance abuse | 1 | 1 | 1 | 11.3 | |||||
smoking status measurement | 1 | 1 | 1 | 2.1 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 0 | 7.7 | 13.4 | ||||
antisocial behaviour measurement | 1 | 11.3 | |||||
1 | 11.3 | ||||||
substance abuse | 1 | 11.3 | |||||
smoking status measurement | 1 | 2.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily J member 2 | VGNC:6118 | 456896 | |||||
Macaque | cytochrome P450 2J2 | 693631 | ||||||
Mouse | MGI:1921769 | 74519 | ||||||
Rat | RGD:620007 | 65210 | ||||||
Dog | cytochrome P450 family 2 subfamily J member 2 | VGNC:50354 | 610195 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily J member 2 | |||||
Macaque | cytochrome P450 2J2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 2 subfamily J member 2 | |||||
Publication Statistics
PubMed Score 245.51
PubMed score by year
PubTator Score 138.83
PubTator score by year
Related Publications
Text Mined References (112)
GeneRif Annotations (89)
Items per page:
0 of 0
PMID | Year | Title |
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