Protein Summary
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
- ENST00000371204
- ENSP00000360247
- ENSG00000134716
- CPJ2
- CYPIIJ2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.88 | ||
molecular function | 0.81 | ||
histone modification site profile | 0.78 | ||
biological term | 0.7 | ||
virus perturbation | 0.68 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.99 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 308 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.99 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 308 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (6)
1 – 6 of 6
Pathways (24)
Reactome (10)
KEGG (6)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Fatty acid metabolism | ||||
Fatty acids | ||||
Gene Ontology Terms (23)
Functions (10)
Components (5)
Processes (8)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (95)
1 – 10 of 95
MINDY2
Novelty: 0.5060241
p_int: 0.999999771
p_ni: 1.24e-7
p_wrong: 1.05e-7
Score: 0.252
Data Source: BioPlex,STRINGDB
TIPIN
Novelty: 0.03596048
p_int: 0.999996851
p_ni: 0.000002839
p_wrong: 3.1e-7
Data Source: BioPlex
ECPAS
Novelty: 0.05663049
p_int: 0.999996236
p_ni: 0.000003764
Data Source: BioPlex
NELFB
Novelty: 0.07360458
p_int: 0.999879617
p_ni: 0.000120383
Data Source: BioPlex
PDE4DIP
Novelty: 0.04181178
p_int: 0.999696229
p_ni: 0.000264254
p_wrong: 0.000039516
Data Source: BioPlex
USP25
Family: Enzyme
Novelty: 0.02945953
p_int: 0.999382772
p_ni: 0.000617228
Data Source: BioPlex
PKD2
Family: IC
Novelty: 0.00208049
p_int: 0.999189282
p_ni: 0.000810718
Data Source: BioPlex
VPS28
Novelty: 0.04542177
p_int: 0.999017469
p_ni: 0.000970666
p_wrong: 0.000011865
Data Source: BioPlex
LRBA
Novelty: 0.00096206
p_int: 0.998352227
p_ni: 0.001647773
Data Source: BioPlex
NELFE
Novelty: 0.03438261
p_int: 0.997102325
p_ni: 0.00289629
p_wrong: 0.000001385
Data Source: BioPlex
Publication Statistics
PubMed Score 173.99
PubMed score by year
PubTator Score 138.83
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQL
1-70
FVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF
70-140
TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQ
140-210
LLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDA
210-280
YLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQ
280-350
PSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT
350-420
FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITIS
420-490
PVSHRLCAVPQV
490-502
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV
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