You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BRCA2
Breast cancer type 2 susceptibility protein

Protein Summary
Description
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380152
  • ENSP00000369497
  • ENSG00000139618
  • ENST00000544455
  • ENSP00000439902

Symbol
  • FACD
  • FANCD1
  • FAD
  • FACD
  • FAD1
  • GLM3
  • BRCC2
  • FANCD
  • PNCA2
  • FANCD1
  • XRCC11
  • BROVCA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
protein domain
0.92
histone modification site profile
0.9
hub protein
0.88
phenotype
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4185.78   (req: < 5)
Gene RIFs: 1208   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4185.78   (req: >= 5)
Gene RIFs: 1208   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.8
95.7
3
1
0
1.7
92.1
2
1
0
1.8
92.1
2
2
0
1.9
81.5
low density lipoprotein cholesterol measurement
4
3
5
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
95.7
0
1.7
92.1
0
1.8
92.1
0
1.9
81.5
low density lipoprotein cholesterol measurement
5
80
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA2, DNA repair associated
VGNC:10496
452526
Macaque
BRCA2, DNA repair associated
721981
Mouse
MGI:109337
12190
Rat
RGD:2219
360254
Dog
BRCA2, DNA repair associated
VGNC:38517
474180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA2, DNA repair associated
Macaque
BRCA2, DNA repair associated
Mouse
Rat
Dog
BRCA2, DNA repair associated
Protein Structure (2 Structures, 12 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
Cell Cycle
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Gene Ontology Terms (44)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (379)
1 – 10 of 379
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.998314682
p_ni: 0.001685318
Score: 0.211
Data Source: BioPlex,STRINGDB
HSPB8
Tbio
Novelty: 0.00298618
p_int: 0.994084632
p_ni: 0.005915368
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.989335386
p_ni: 0.010664614
Data Source: BioPlex
TSGA10IP
Tdark
Novelty: 20.75428866
p_int: 0.972058521
p_ni: 0.027941479
Data Source: BioPlex
TEX45
Tdark
Novelty: 5.55785981
p_int: 0.97171632
p_ni: 0.02828368
Data Source: BioPlex
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.965396737
p_ni: 0.034603263
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.956424924
p_ni: 0.043575076
Data Source: BioPlex
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.954349042
p_ni: 0.045650958
Score: 0.564
Data Source: BioPlex,STRINGDB
PPM1E
Tbio
Family: Enzyme
Novelty: 0.08964901
p_int: 0.908500271
p_ni: 0.091499729
Score: 0.201
Data Source: BioPlex,STRINGDB
PRELID2
Tdark
Novelty: 0.38276284
p_int: 0.898765127
p_ni: 0.101234873
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  4185.78

PubMed score by year
PubTator Score  4427.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: