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Tchem
P2RY4
P2Y purinoceptor 4

Protein Summary
Description
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374519
  • ENSP00000363643
  • ENSG00000186912

Symbol
  • NRU
  • NRU
  • P2P
  • UNR
  • P2Y4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
cell type or tissue
0.56
tissue
0.53
ligand (chemical)
0.51
pathway
0.47


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.97   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.97   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (31)
1 – 10 of 31
reactive blue 2
Rendered image for reactive blue 2
Ap4A
Rendered image for Ap4A
UTP
Rendered image for UTP
MRS4162
Rendered image for MRS4162
4-thio-UTP
Rendered image for 4-thio-UTP
denufosol
Rendered image for denufosol
CHEMBL606210
Rendered image for CHEMBL606210
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrimidinergic receptor P2Y4
VGNC:7462
473656
Macaque
pyrimidinergic receptor P2Y4
695127
Mouse
MGI:1926594
57385
Rat
RGD:61798
63843
Cow
pyrimidinergic receptor P2Y4
VGNC:32529
514653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrimidinergic receptor P2Y4
Macaque
pyrimidinergic receptor P2Y4
Mouse
Rat
Cow
pyrimidinergic receptor P2Y4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51582-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (255)
1 – 10 of 255
ADORA1
Tclin
Family:  GPCR
Novelty:  0.00043697
Score:  0.956
Data Source:  STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.956
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.956
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.928
Data Source:  STRINGDB
P2RY14
Tchem
Family:  GPCR
Novelty:  0.0135462
Score:  0.926
Data Source:  STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.925
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.919
Data Source:  STRINGDB
ADRA2B
Tclin
Family:  GPCR
Novelty:  0.00633206
Score:  0.916
Data Source:  STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
Score:  0.915
Data Source:  STRINGDB
OPRL1
Tchem
Family:  GPCR
Novelty:  0.00186729
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  98.97

PubMed score by year
PubTator Score  155.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer