Tchem P2RX1 P2X purinoceptor 1

Protein Summary

Description

Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P51575
• Q9UK84
• P2X1

Gene Name

• P2RX1

Ensembl ID

• ENST00000225538
• ENSP00000225538
• ENSG00000108405

Symbol

• P2X1
• P2X1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.96
gene perturbation	0.82
cellular component	0.78
cell type or tissue	0.73

Protein Classes

DTO Classes

Protein / Ion Channel / Atp-gated P2x Receptor Cation Channel (P2x Receptor) Family / P2x Purinoceptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.46   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.46   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3