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Tchem
P2RX1
P2X purinoceptor 1

Protein Summary
Description
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225538
  • ENSP00000225538
  • ENSG00000108405

Symbol
  • P2X1
  • P2X1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.96
gene perturbation
0.82
cellular component
0.78
cell type or tissue
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.69   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.69   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
73.2
platelet count
1
1
1
27.5
platelet crit
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
73.2
platelet count
1
27.5
platelet crit
1
7.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 1
VGNC:9500
454439
Macaque
purinergic receptor P2X 1
707658
Mouse
MGI:1098235
18436
Rat
RGD:3240
25505
Dog
purinergic receptor P2X 1
VGNC:44207
491223
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 1
Macaque
purinergic receptor P2X 1
Mouse
Rat
Dog
purinergic receptor P2X 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51575-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (44)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (166)
1 – 10 of 166
TMED8
Tdark
Novelty: 1.41977071
p_int: 0.999999535
p_ni: 4.65e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
GMCL1
Tbio
Novelty: 0.1543762
p_int: 0.999992376
p_ni: 0.000007621
p_wrong: 3e-9
Data Source: BioPlex
PRMT9
Tbio
Family: Enzyme
Novelty: 0.26898134
p_int: 0.99973853
p_ni: 0.00026147
Score: 0.189
Data Source: BioPlex,STRINGDB
GOLPH3L
Tbio
Novelty: 0.30373124
p_int: 0.999286276
p_ni: 0.000713715
p_wrong: 8e-9
Score: 0.546
Data Source: BioPlex,STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.00225882
p_int: 0.99736686
p_ni: 0.00263314
Score: 0.189
Data Source: BioPlex,STRINGDB
PI4K2A
Tbio
Family: Kinase
Novelty: 0.03506675
p_int: 0.993521186
p_ni: 0.005159008
p_wrong: 0.001319806
Score: 0.177
Data Source: BioPlex,STRINGDB
ATE1
Tbio
Family: Enzyme
Novelty: 0.01672896
p_int: 0.9775235
p_ni: 0.0224765
Data Source: BioPlex
GLB1L2
Tdark
Family: Enzyme
Novelty: 1.03866932
p_int: 0.976250878
p_ni: 0.023749122
Score: 0.213
Data Source: BioPlex,STRINGDB
GOLPH3
Tbio
Novelty: 0.00020234
p_int: 0.967570967
p_ni: 0.030603651
p_wrong: 0.001825382
Data Source: BioPlex
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.933892268
p_ni: 0.066107732
Data Source: BioPlex
Publication Statistics
PubMed Score  346.69

PubMed score by year
PubTator Score  194.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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