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Tbio
BCAP31
B-cell receptor-associated protein 31

Protein Classes
Protein Summary
Description
Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345046
  • ENSP00000343458
  • ENSG00000185825
  • ENST00000458587
  • ENSP00000392330
  • ENST00000647529
  • ENSP00000494052

Symbol
  • BAP31
  • DXS1357E
  • CDM
  • DDCH
  • BAP31
  • 6C6-AG
  • DXS1357E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.99
disease perturbation
0.96
co-expressed gene
0.93
kinase perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
B-cell receptor associated protein 31
696663
Mouse
MGI:1350933
27061
Rat
RGD:1302944
293852
Dog
B cell receptor associated protein 31
VGNC:38397
481080
Horse
B cell receptor associated protein 31
VGNC:15781
100058834
Species
Name
OMA
EggNOG
Inparanoid
Macaque
B-cell receptor associated protein 31
Mouse
Rat
Dog
B cell receptor associated protein 31
Horse
B cell receptor associated protein 31
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51572-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (28)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (149)
1 – 10 of 149
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.987564846
p_ni: 0.012435154
Data Source: BioPlex
UBAC1
Tbio
Novelty: 0.00122518
p_int: 0.982466395
p_ni: 0.017533605
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.952820545
p_ni: 0.047179454
p_wrong: 1e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
CYB5A
Tbio
Novelty: 0.00047376
p_int: 0.851396712
p_ni: 0.148603288
Score: 0.554
Data Source: BioPlex,STRINGDB
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.82361494
p_ni: 0.17638506
Data Source: BioPlex
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.971
Data Source: Reactome,STRINGDB
RER1
Tbio
Novelty: 0.02748687
Score: 0.955
Data Source: STRINGDB
DNM1L
Tbio
Novelty: 0.00151314
Score: 0.945
Data Source: STRINGDB
PHB
Tbio
Novelty: 0.00178383
Score: 0.899
Data Source: STRINGDB
CISD1
Tchem
Novelty: 0.0118675
Score: 0.883
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.22

PubMed score by year
PubTator Score  53.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer