Tbio BCAP31 B-cell receptor-associated protein 31

Protein Summary

Description

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P51572
• B3KQ79
• D3DWV5
• Q13836
• Q96CF0
• BCR-associated protein 31

Gene Name

• BCAP31

Ensembl ID

• ENST00000345046
• ENSP00000343458
• ENSG00000185825
• ENST00000458587
• ENSP00000392330
• ENST00000647529
• ENSP00000494052

Symbol

• BAP31
• DXS1357E
• CDM
• DDCH
• BAP31
• 6C6-AG
• DXS1357E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
virus perturbation	0.99
disease perturbation	0.96
co-expressed gene	0.93
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / B-cell Receptor-associated Protein 31

Protein / Membrane Traffic Protein / B-cell Receptor-associated Protein 31

DTO Classes

Protein / Transporter / B-cell Receptor-associated Protein 31

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.51   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 466   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.51   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0