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Tbio
SSR4
Translocon-associated protein subunit delta

Protein Summary
Description
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320857
  • ENSP00000317331
  • ENSG00000180879
  • ENST00000370086
  • ENSP00000359103
  • ENST00000370087
  • ENSP00000359104

Symbol
  • TRAPD
  • CDG1Y
  • TRAPD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.95
histone modification site profile
0.92
transcription factor perturbation
0.91
hub protein
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
40.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 4
VGNC:10405
465928
Macaque
signal sequence receptor subunit 4
697266
Mouse
MGI:1099464
20832
Rat
RGD:62034
29435
Dog
signal sequence receptor subunit 4
VGNC:46840
481082
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal sequence receptor subunit 4
Macaque
signal sequence receptor subunit 4
Mouse
Rat
Dog
signal sequence receptor subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51571-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (175)
1 – 10 of 175
SSR3
Tbio
Novelty:  0.05838475
Score:  0.998
Data Source:  Reactome,STRINGDB
SSR2
Tbio
Novelty:  0.01383689
Score:  0.997
Data Source:  Reactome,STRINGDB
SSR1
Tbio
Novelty:  0.02009694
Score:  0.995
Data Source:  Reactome,STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
Score:  0.993
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.992
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.99
Data Source:  STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
Score:  0.987
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.986
Data Source:  STRINGDB
SEC11A
Tbio
Family:  Enzyme
Novelty:  0.05764568
Score:  0.978
Data Source:  STRINGDB
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  23.30

PubMed score by year
PubTator Score  10.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer