SSR4
Translocon-associated protein subunit delta
Protein Summary
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
- ENST00000320857
- ENSP00000317331
- ENSG00000180879
- ENST00000370086
- ENSP00000359103
- ENST00000370087
- ENSP00000359104
- TRAPD
- CDG1Y
- TRAPD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.95 | ||
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.91 | ||
hub protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.32 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 153 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.32 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 153 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0