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Tbio
IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Protein Summary
Description
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217901
  • ENSP00000217901
  • ENSG00000067829
  • ENST00000370092
  • ENSP00000359110

Symbol
  • H-IDHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
histone modification site profile
0.92
transcription factor perturbation
0.88
co-expressed gene
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Mitochondrial protein import
Protein localization
Pyruvate metabolism and Citric Acid (TCA) cycle
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (167)
1 – 10 of 167
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
p_int: 1
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
IDH3A
Tbio
Family: Enzyme
Novelty: 0.02027198
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.793372201
p_ni: 0.206627799
Score: 0.917
Data Source: BioPlex,STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.998
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.998
Data Source: STRINGDB
IDH1
Tclin
Family: Enzyme
Novelty: 0.0004831
Score: 0.995
Data Source: STRINGDB
TIMM44
Tbio
Family: Enzyme
Novelty: 0.020862
Score: 0.982
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.975
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.968
Data Source: STRINGDB
OGDHL
Tbio
Family: Enzyme
Novelty: 0.05079572
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.99

PubMed score by year
PubTator Score  2.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer