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Tchem
SMARCA4
Transcription activator BRG1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344626
  • ENSP00000343896
  • ENSG00000127616
  • ENST00000429416
  • ENSP00000395654
  • ENST00000444061
  • ENSP00000392837
  • ENST00000541122
  • ENSP00000445036
  • ENST00000589677
  • ENSP00000464778
  • ENST00000590574
  • ENSP00000466963
  • ENST00000643296
  • ENSP00000496635
  • ENST00000644737
  • ENSP00000495548
  • ENST00000645460
  • ENSP00000494463
  • ENST00000646484
  • ENSP00000495536
  • ENST00000646510
  • ENSP00000494772
  • ENST00000647230
  • ENSP00000494676

Symbol
  • BAF190A
  • BRG1
  • SNF2B
  • SNF2L4
  • BRG1
  • CSS4
  • SNF2
  • SWI2
  • MRD16
  • RTPS2
  • BAF190
  • SNF2L4
  • SNF2LB
  • hSNF2b
  • BAF190A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein complex
1
protein domain
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.06   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.06   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
14
22
6.2
99.5
total cholesterol measurement
7
13
18
6.2
99.2
6
5
2
1.1
95.8
vitamin D measurement
3
2
3
93.6
lipid measurement
2
2
1
32.9
82.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
22
6.2
99.5
total cholesterol measurement
18
6.2
99.2
2
1.1
95.8
vitamin D measurement
3
93.6
lipid measurement
1
32.9
82.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88192
20586
Rat
RGD:621728
171379
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
VGNC:46530
476710
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
VGNC:23319
100054949
Cow
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
VGNC:34987
414274
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Cow
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51532-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (78)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Cytokine Signaling in Immune system
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Cytokine Signaling in Immune system
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (539)
1 – 10 of 539
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999972469
p_ni: 0.000027531
Score: 0.879
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999967779
p_ni: 0.000032221
Score: 0.999
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.0403366
p_int: 0.99996467
p_ni: 0.00003533
Score: 0.948
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.999944109
p_ni: 0.000055891
Score: 0.95
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999907206
p_ni: 0.000092794
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999874226
p_ni: 0.000125774
Score: 0.981
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999715668
p_ni: 0.000284332
Score: 0.876
Data Source: BioPlex,STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
p_int: 0.998159113
p_ni: 0.001840887
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.01748089
p_int: 0.976222051
p_ni: 0.023777949
Score: 0.999
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.801467813
p_ni: 0.198532187
Score: 0.243
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  944.06

PubMed score by year
PubTator Score  713.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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