Tbio NOVA1 RNA-binding protein Nova-1

Protein Summary

Description

May regulate RNA splicing or metabolism in a specific subset of developing neurons. This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51513
• A8K0S4
• A8K4Q7
• D3DS81
• D3DS82
• Q6B004

Gene Name

• NOVA1

Ensembl ID

• ENST00000344429
• ENSP00000342387
• ENSG00000139910
• ENST00000465357
• ENSP00000447391
• ENST00000539517
• ENSP00000438875

Symbol

• Nova-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.72
histone modification site profile	0.65
cellular component	0.61
microRNA	0.61
trait	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Rna-binding Protein Nova-1

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Rna-binding Protein Nova-1

Protein / Enzyme Modulator / Rna-binding Protein Nova-1

Protein / ... / Serine Protease / Rna-binding Protein Nova-1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Rna-binding Protein Nova-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.31   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.31   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0