Tchem MMP16 Matrix metalloproteinase-16

Protein Summary

Description

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• P51512
• B2RAN7
• Q14824
• Q52H48
• MMP-16

Gene Name

• MMP16

Ensembl ID

• ENST00000286614
• ENSP00000286614
• ENSG00000156103

Symbol

• C8orf57
• MMPX2
• MMP-X2
• C8orf57
• MT-MMP2
• MT-MMP3
• MT3-MMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.89
disease	0.78
cell type or tissue	0.76
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-16

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.68   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 399   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.68   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0