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Tchem
MMP15
Matrix metalloproteinase-15

Protein Summary
Description
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219271
  • ENSP00000219271
  • ENSG00000102996

Symbol
  • MMP-15
  • MT2MMP
  • MTMMP2
  • SMCP-2
  • MT2-MMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.92
transcription factor perturbation
0.8
gene perturbation
0.77
small molecule perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.73   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 459   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.73   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
3
3
92.4
FEV/FEC ratio
1
1
1
82.1
serum alanine aminotransferase measurement
1
1
0
6.4
44.2
1
2
0
1.1
26.6
pulmonary function measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
92.4
FEV/FEC ratio
1
82.1
serum alanine aminotransferase measurement
0
6.4
44.2
0
1.1
26.6
pulmonary function measurement
1
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 15
VGNC:5838
467988
Macaque
matrix metallopeptidase 15
706523
Mouse
MGI:109320
17388
Rat
RGD:1308937
291848
Dog
matrix metallopeptidase 15
VGNC:49926
487257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 15
Macaque
matrix metallopeptidase 15
Mouse
Rat
Dog
matrix metallopeptidase 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (61)
1 – 10 of 61
TRPV3
Tchem
Family:  IC
Novelty:  0.00533583
p_int:  0.999999974
p_ni:  5e-9
p_wrong:  2.1e-8
Data Source:  BioPlex
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.978
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.942
Data Source:  STRINGDB
NID1
Tbio
Novelty:  0.00169075
Score:  0.926
Data Source:  Reactome,STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.925
Data Source:  Reactome,STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.906
Data Source:  STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.874
Data Source:  STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
Score:  0.694
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.665
Data Source:  STRINGDB
ADAM22
Tbio
Family:  Enzyme
Novelty:  0.01981755
Score:  0.657
Data Source:  STRINGDB
Publication Statistics
PubMed Score  64.73

PubMed score by year
PubTator Score  57.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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