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Tchem
DUSP3
Dual specificity protein phosphatase 3

Protein Summary
Description
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226004
  • ENSP00000226004
  • ENSG00000108861

Symbol
  • VHR
  • VHR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.97
disease perturbation
0.96
biological process
0.94
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.6   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.6   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ERKs are inactivated
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ERKs are inactivated
Immune System
Innate Immune System
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (91)
1 – 10 of 91
C6orf120
Tdark
Novelty: 0.6440678
p_int: 0.999901099
p_ni: 0.000098896
p_wrong: 4e-9
Data Source: BioPlex
TMUB1
Tbio
Novelty: 0.21276596
p_int: 0.998157728
p_ni: 0.001842272
Data Source: BioPlex
C16orf71
Tdark
p_int: 0.997803513
p_ni: 0.002196487
Score: 0.175
Data Source: BioPlex,STRINGDB
TMUB2
Tdark
Novelty: 15
p_int: 0.996527658
p_ni: 0.000288482
p_wrong: 0.00318386
Score: 0.171
Data Source: BioPlex,STRINGDB
TMBIM6
Tbio
Novelty: 0.00311338
p_int: 0.996118158
p_ni: 0.003880719
p_wrong: 0.000001123
Data Source: BioPlex
RNF170
Tbio
Family: Enzyme
Novelty: 0.21818182
p_int: 0.994636789
p_ni: 0.005363205
p_wrong: 6e-9
Data Source: BioPlex
ERLIN1
Tbio
Novelty: 0.09717314
p_int: 0.990679362
p_ni: 0.009320616
p_wrong: 2.2e-8
Score: 0.319
Data Source: BioPlex,STRINGDB
ERLIN2
Tbio
Novelty: 0.04703481
p_int: 0.985612714
p_ni: 0.014387286
Score: 0.424
Data Source: BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty: 0.43010753
p_int: 0.984791669
p_ni: 0.014546794
p_wrong: 0.000661537
Score: 0.527
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.16730745
p_int: 0.979282746
p_ni: 0.020676553
p_wrong: 0.000040701
Data Source: BioPlex
Publication Statistics
PubMed Score  149.60

PubMed score by year
PubTator Score  111.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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