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Tbio
DAP3
28S ribosomal protein S29, mitochondrial

Protein Summary
Description
Involved in mediating interferon-gamma-induced cell death. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343043
  • ENSP00000341692
  • ENSG00000132676
  • ENST00000368336
  • ENSP00000357320
  • ENST00000421487
  • ENSP00000412605
  • ENST00000471642
  • ENSP00000476592
  • ENST00000535183
  • ENSP00000445003

Symbol
  • MRPS29
  • DAP-3
  • S29mt
  • MRPS29
  • MRP-S29
  • bMRP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
virus perturbation
0.92
co-expressed gene
0.89
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (217)
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.999999805
p_ni:  1.95e-7
Score:  0.208
Data Source:  BioPlex,STRINGDB
PNMA6A
Tbio
Novelty:  0.05538258
p_int:  0.99963453
p_ni:  0.000018992
p_wrong:  0.000346478
Score:  0.345
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999574055
p_ni:  0.000425945
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.998430101
p_ni:  0.001569899
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.998132185
p_ni:  0.001867815
Score:  0.962
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.997246174
p_ni:  0.002753826
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.995935964
p_ni:  0.004064036
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.99391463
p_ni:  0.00608537
Score:  0.988
Data Source:  BioPlex,STRINGDB
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.993823424
p_ni:  0.006176576
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.988171627
p_ni:  0.011828373
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
1
1
74.8
serum gamma-glutamyl transferase measurement
1
1
1
53.7
appendicular lean mass
1
2
2
53.1
cancer antigen 15.3 measurement
1
1
1
50.6
body mass index
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
74.8
serum gamma-glutamyl transferase measurement
1
53.7
appendicular lean mass
2
53.1
cancer antigen 15.3 measurement
1
50.6
body mass index
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death associated protein 3
VGNC:12999
740895
Macaque
death associated protein 3
719314
Mouse
MGI:1929538
65111
Rat
RGD:1305339
295238
Dog
death associated protein 3
VGNC:39769
480127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death associated protein 3
Macaque
death associated protein 3
Mouse
Rat
Dog
death associated protein 3
Publication Statistics
PubMed Score 25.57
PubMed score by year
PubTator Score 31.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title