You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DAP3
28S ribosomal protein S29, mitochondrial

Protein Summary
Description
Involved in mediating interferon-gamma-induced cell death. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343043
  • ENSP00000341692
  • ENSG00000132676
  • ENST00000368336
  • ENSP00000357320
  • ENST00000421487
  • ENSP00000412605
  • ENST00000471642
  • ENSP00000476592
  • ENST00000535183
  • ENSP00000445003

Symbol
  • MRPS29
  • DAP-3
  • S29mt
  • MRPS29
  • MRP-S29
  • bMRP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
virus perturbation
0.92
co-expressed gene
0.89
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.34   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.34   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
66.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
66.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death associated protein 3
VGNC:12999
740895
Macaque
death associated protein 3
719314
Mouse
MGI:1929538
65111
Rat
RGD:1305339
295238
Dog
death associated protein 3
VGNC:39769
480127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death associated protein 3
Macaque
death associated protein 3
Mouse
Rat
Dog
death associated protein 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (217)
1 – 10 of 217
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.999999805
p_ni: 1.95e-7
Score: 0.208
Data Source: BioPlex,STRINGDB
PNMA6A
Tbio
Novelty: 0.05538258
p_int: 0.99963453
p_ni: 0.000018992
p_wrong: 0.000346478
Score: 0.345
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.999574055
p_ni: 0.000425945
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.998430101
p_ni: 0.001569899
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.998132185
p_ni: 0.001867815
Score: 0.962
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.997246174
p_ni: 0.002753826
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.995935964
p_ni: 0.004064036
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.99391463
p_ni: 0.00608537
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS35
Tdark
Novelty: 6.44240335
p_int: 0.993823424
p_ni: 0.006176576
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.988171627
p_ni: 0.011828373
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.34

PubMed score by year
PubTator Score  31.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: