Tbio DAP3 28S ribosomal protein S29, mitochondrial

Protein Summary

Description

Involved in mediating interferon-gamma-induced cell death. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P51398
• B4DP59
• B4DY62
• E7EM60
• Q13044
• Q68CT7
• Q96Q20
• MRP-S29

Gene Name

• DAP3

Ensembl ID

• ENST00000343043
• ENSP00000341692
• ENSG00000132676
• ENST00000368336
• ENSP00000357320
• ENST00000421487
• ENSP00000412605
• ENST00000471642
• ENSP00000476592
• ENST00000535183
• ENSP00000445003

Symbol

• MRPS29
• DAP-3
• S29mt
• MRPS29
• MRP-S29
• bMRP-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
interacting protein	0.99
virus perturbation	0.92
co-expressed gene	0.89
histone modification site profile	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 28s Ribosomal Protein S29, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 28s Ribosomal Protein S29, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 427   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0