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Tchem
PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334661
  • ENSP00000335600
  • ENSG00000187091
  • ENST00000463876
  • ENSP00000430344

Symbol
  • NDNC3
  • PLC-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.96
molecular function
0.9
metabolite
0.89
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.66   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.66   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1916340
chemical structure image
Pathways (29)
Inositol phosphate metabolism (R-HSA-1483249)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Protein-Protein Interactions (119)
1 – 10 of 119
FBXL4
Tbio
Novelty: 0.04286856
p_int: 0.999997624
p_ni: 0.000002375
Data Source: BioPlex
IL31RA
Tbio
Novelty: 0.00737445
p_int: 0.999964203
p_ni: 0.000035797
Data Source: BioPlex
FBXO3
Tbio
Novelty: 0.01701102
p_int: 0.999849887
p_ni: 0.000149478
p_wrong: 6.36e-7
Data Source: BioPlex
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.999833447
p_ni: 0.000165333
p_wrong: 0.00000122
Data Source: BioPlex
RAB11B
Tbio
Family: Enzyme
Novelty: 0.00557558
p_int: 0.999681519
p_ni: 0.00031799
p_wrong: 4.91e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
TEX35
Tdark
Novelty: 0.5605055
p_int: 0.999484001
p_ni: 0.000515957
p_wrong: 4.2e-8
Data Source: BioPlex
PYHIN1
Tbio
Novelty: 0.06662677
p_int: 0.997515168
p_ni: 0.002476518
p_wrong: 0.000008314
Score: 0.177
Data Source: BioPlex,STRINGDB
GPBP1
Tbio
Novelty: 0.18802498
p_int: 0.997439809
p_ni: 0.002559935
p_wrong: 2.55e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
USP6NL
Tbio
Novelty: 0.09667588
p_int: 0.997365975
p_ni: 0.002260072
p_wrong: 0.000373954
Data Source: BioPlex
RBM24
Tbio
Novelty: 0.04562076
p_int: 0.992291999
p_ni: 0.000235523
p_wrong: 0.007472478
Data Source: BioPlex
Publication Statistics
PubMed Score  125.66

PubMed score by year
PubTator Score  115.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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