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Tbio
SCNN1D
Amiloride-sensitive sodium channel subunit delta

Protein Summary
Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325425
  • ENSP00000321594
  • ENSG00000162572
  • ENST00000338555
  • ENSP00000339504
  • ENST00000400928
  • ENSP00000383717

Symbol
  • DNACH
  • ENaCd
  • SCNED
  • dNaCh
  • ENaCdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
virus perturbation
0.59
tissue sample
0.58
cellular component
0.53
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (72)
1 – 10 of 72
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999999055
p_ni: 9.45e-7
Data Source: BioPlex
ABHD16A
Tchem
Family: Enzyme
Novelty: 0.04797219
p_int: 0.999989121
p_ni: 0.000010607
p_wrong: 2.72e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
MTFR2
Tbio
Novelty: 0.20272025
p_int: 0.999943084
p_ni: 0.000056914
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
TAP2
Tbio
Novelty: 0.0390555
p_int: 0.998518901
p_ni: 0.001353559
p_wrong: 0.000127541
Score: 0.209
Data Source: BioPlex,STRINGDB
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.992353478
p_ni: 0.004468647
p_wrong: 0.003177876
Data Source: BioPlex
CLSTN3
Tbio
Novelty: 0.10438143
p_int: 0.991902644
p_ni: 0.008097356
Score: 0.295
Data Source: BioPlex,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.990930152
p_ni: 0.009069848
Data Source: BioPlex
AMIGO1
Tbio
Novelty: 0.00864791
p_int: 0.98655296
p_ni: 0.013430323
p_wrong: 0.000016716
Score: 0.17
Data Source: BioPlex,STRINGDB
CFAP74
Tdark
Novelty: 0.37177561
p_int: 0.985974846
p_ni: 0.013750201
p_wrong: 0.000274953
Score: 0.25
Data Source: BioPlex,STRINGDB
LRRC3
Tdark
Novelty: 0.13484671
p_int: 0.974907735
p_ni: 0.019007983
p_wrong: 0.006084282
Score: 0.17
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.34

PubMed score by year
PubTator Score  14.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer