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Tclin
SCNN1G
Amiloride-sensitive sodium channel subunit gamma

Protein Classes
Protein Summary
Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300061
  • ENSP00000300061
  • ENSG00000166828

Symbol
  • PHA1
  • BESC3
  • ENaCg
  • LDLS2
  • SCNEG
  • ENaCgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
gene perturbation
0.76
cellular component
0.65
histone modification site profile
0.62
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.14   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.14   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Pathways (5)
Ion channel transport (R-HSA-983712)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (89)
1 – 10 of 89
NEDD4L
Tbio
Family: Enzyme
Novelty: 0.00294229
Score: 0.991
Data Source: STRINGDB
SGK1
Tchem
Family: Kinase
Novelty: 0.00194497
Score: 0.972
Data Source: STRINGDB
WNK4
Tbio
Family: Kinase
Novelty: 0.00882642
Score: 0.967
Data Source: STRINGDB
WNK1
Tchem
Family: Kinase
Novelty: 0.00147233
Score: 0.958
Data Source: STRINGDB
SCNN1B
Tclin
Family: IC
Novelty: 0.0159121
Score: 0.957
Data Source: Reactome,STRINGDB
SCNN1A
Tclin
Family: IC
Novelty: 0.01452921
Score: 0.949
Data Source: Reactome,STRINGDB
SCNN1D
Tbio
Family: IC
Novelty: 0.06253257
Score: 0.945
Data Source: Reactome,STRINGDB
WNK3
Tchem
Family: Kinase
Novelty: 0.04155741
Score: 0.938
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.931
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  133.14

PubMed score by year
PubTator Score  125.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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