ATP4B
Potassium-transporting ATPase subunit beta
Protein Summary
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
- ENST00000335288
- ENSP00000334216
- ENSG00000186009
- ATP6B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
co-expressed gene | 0.91 | ||
kinase perturbation | 0.71 | ||
microRNA | 0.65 | ||
gene perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.56 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.56 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 10
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
Active Ligands (0)
Protein-Protein Interactions (38)
Nearest Tclin Targets
Pathways (7)
Reactome (3)
KEGG (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Ion transport by P-type ATPases | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 38.2 | |||||
sleep measurement | 1 | 1 | 1 | 26.6 | |||||
body height | 1 | 1 | 1 | 10.6 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 38.2 | |||||
sleep measurement | 1 | 26.6 | |||||
body height | 1 | 10.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting subunit beta | VGNC:7827 | 738405 | |||||
Mouse | MGI:88114 | 11945 | ||||||
Rat | RGD:2178 | 24217 | ||||||
Dog | ATPase H+/K+ transporting subunit beta | VGNC:38263 | 404020 | |||||
Horse | ATPase H+/K+ transporting subunit beta | VGNC:15658 | 100069135 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting subunit beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase H+/K+ transporting subunit beta | |||||
Horse | ATPase H+/K+ transporting subunit beta | |||||
Publication Statistics
PubMed Score 14.56
PubMed score by year
PubTator Score 8.52
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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