Tclin ATP4B Potassium-transporting ATPase subunit beta

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Potassium-transporting Atpase Subunit Beta

DTO Classes

Protein / Transporter / P-type Atpases / H+/k+-atpases / Potassium-transporting Atpase Subunit Beta

Protein Summary

Description

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51164
• B1B0N8

Gene Name

• ATP4B

Ensembl ID

• ENST00000335288
• ENSP00000334216
• ENSG00000186009

Symbol

• ATP6B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
co-expressed gene	0.91
kinase perturbation	0.71
microRNA	0.65
gene perturbation	0.61

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.56   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.56   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10

Approved Drugs (10)

Explore Approved Drugs

1 – 10 of 10

lansoprazole

ATP4BTclin Transporter

INHIBITOR :

esomeprazole

ATP4BTclin Transporter

INHIBITOR :

omeprazole

ATP4BTclin Transporter

INHIBITOR IC50 : 5.7

pantoprazole

ATP4BTclin Transporter

INHIBITOR :

rabeprazole

ATP4BTclin Transporter

INHIBITOR :

dexlansoprazole

ATP4BTclin Transporter

INHIBITOR :

vonoprazan

ATP4BTclin Transporter

INHIBITOR Ki : 8

revaprazan

ATP4BTclin Transporter

INHIBITOR :

dexrabeprazole

ATP4BTclin Transporter

INHIBITOR :

ilaprazole

ATP4BTclin Transporter

INHIBITOR :

GWAS Traits (3)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	1	1		38.2
sleep measurement	EFO_0004870	1	1	1		26.6
body height	EFO_0004339	1	1	1		10.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1		38.2
sleep measurement	EFO_0004870	1		26.6
body height	EFO_0004339	1		10.6

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATPase H+/K+ transporting subunit beta	VGNC:7827	738405
Mouse	ATPase, H+/K+ exchanging, beta polypeptide	MGI:88114	11945
Rat	ATPase H+/K+ transporting subunit beta	RGD:2178	24217
Dog	ATPase H+/K+ transporting subunit beta	VGNC:38263	404020
Horse	ATPase H+/K+ transporting subunit beta	VGNC:15658	100069135

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATPase H+/K+ transporting subunit beta
Mouse	ATPase, H+/K+ exchanging, beta polypeptide
Rat	ATPase H+/K+ transporting subunit beta
Dog	ATPase H+/K+ transporting subunit beta
Horse	ATPase H+/K+ transporting subunit beta

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P51164-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)

Reactome (3)

KEGG (4)

Ion channel transport (R-HSA-983712)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Ion transport by P-type ATPases	55 targets	R-HSA-936837
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Ion transport by P-type ATPases	55 targets	R-HSA-936837
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (12)

Functions (2)

Components (2)

Processes (8)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ATPase activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
potassium:proton exchanging ATPase activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (38)

Explore Interacting Targets

1 – 10 of 38

• See Interactions on String-DB

ATP4A

Tclin

Family:  Transporter

Novelty:  0.00008783

Score:  0.988

Data Source:  Reactome,STRINGDB

ATP12A

Tchem

Family:  Transporter

Novelty:  0.00008793

Score:  0.98

Data Source:  Reactome,STRINGDB

LHPP

Tbio

Family:  Enzyme

Novelty:  0.0356879

Score:  0.928

Data Source:  STRINGDB

PPA2

Tbio

Family:  Enzyme

Novelty:  0.01790138

Score:  0.919

Data Source:  STRINGDB

PPA1

Tbio

Family:  Enzyme

Novelty:  0.00109986

Score:  0.915

Data Source:  STRINGDB

ATP1A1

Tclin

Family:  Transporter

Novelty:  0.01078788

Score:  0.81

Data Source:  STRINGDB

ATP1A2

Tclin

Family:  Transporter

Novelty:  0.00606202

Score:  0.733

Data Source:  STRINGDB

ATP1A3

Tclin

Family:  Transporter

Novelty:  0.00485594

Score:  0.733

Data Source:  STRINGDB

FXYD2

Tclin

Family:  Enzyme

Novelty:  0.0196518

Score:  0.656

Data Source:  STRINGDB

ATP1A4

Tclin

Family:  Transporter

Novelty:  0.01011201

Score:  0.654

Data Source:  STRINGDB

Publication Statistics

PubMed Score  14.56

PubMed score by year

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PubTator Score  8.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Hydrogen ion transport
Ion transport
Membrane
Potassium
Potassium transport

GWAS Trait Find Similar Targets

No Header	No Header
body height
mean corpuscular volume
sleep measurement

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype