ATP4B
Potassium-transporting ATPase subunit beta
Protein Classes
Protein Summary
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
- ENST00000335288
- ENSP00000334216
- ENSG00000186009
- ATP6B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
co-expressed gene | 0.91 | ||
kinase perturbation | 0.71 | ||
microRNA | 0.65 | ||
gene perturbation | 0.61 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.94 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.94 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 10
Approved Drugs (10)
1 – 10 of 10
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting subunit beta | VGNC:7827 | 738405 | |||||
Mouse | MGI:88114 | 11945 | ||||||
Rat | RGD:2178 | 24217 | ||||||
Dog | ATPase H+/K+ transporting subunit beta | VGNC:38263 | 404020 | |||||
Horse | ATPase H+/K+ transporting subunit beta | VGNC:15658 | 100069135 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting subunit beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase H+/K+ transporting subunit beta | |||||
Horse | ATPase H+/K+ transporting subunit beta | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (7)
Reactome (3)
KEGG (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Ion transport by P-type ATPases | ||||
Transport of small molecules | ||||
Gene Ontology Terms (12)
Functions (2)
Components (2)
Processes (8)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (38)
1 – 10 of 38
ATP4A
Family: Transporter
Novelty: 0.00008783
Score: 0.988
Data Source: Reactome,STRINGDB
ATP12A
Family: Transporter
Novelty: 0.00008793
Score: 0.98
Data Source: Reactome,STRINGDB
LHPP
Family: Enzyme
Novelty: 0.0356879
Score: 0.928
Data Source: STRINGDB
PPA2
Family: Enzyme
Novelty: 0.01790138
Score: 0.919
Data Source: STRINGDB
PPA1
Family: Enzyme
Novelty: 0.00109986
Score: 0.915
Data Source: STRINGDB
ATP1A1
Family: Transporter
Novelty: 0.01078788
Score: 0.81
Data Source: STRINGDB
ATP1A2
Family: Transporter
Novelty: 0.00606202
Score: 0.733
Data Source: STRINGDB
ATP1A3
Family: Transporter
Novelty: 0.00485594
Score: 0.733
Data Source: STRINGDB
FXYD2
Family: Enzyme
Novelty: 0.0196518
Score: 0.656
Data Source: STRINGDB
ATP1A4
Family: Transporter
Novelty: 0.01011201
Score: 0.654
Data Source: STRINGDB
Publication Statistics
PubMed Score 13.94
PubMed score by year
PubTator Score 8.52
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: