Protein Summary
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alte ...more
- ENST00000393980
- ENSP00000377549
- ENSG00000170231
- ENST00000402432
- ENSP00000385433
- ILBP
- ILLBP
- ILBP
- I-15P
- I-BAP
- ILBP3
- ILLBP
- I-BABP
- I-BALB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.71 | ||
transcription factor | 0.64 | ||
disease perturbation | 0.62 | ||
cell type or tissue | 0.51 | ||
metabolite | 0.48 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.68 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.68 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 3 | 3 | 3 | 86.5 | |||||
mean platelet volume | 1 | 1 | 1 | 37.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 86.5 | |||||
mean platelet volume | 1 | 37.8 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fatty acid binding protein 6 | VGNC:6871 | 107974918 | |||||
Macaque | fatty acid binding protein 6 | 695439 | ||||||
Mouse | MGI:96565 | 16204 | ||||||
Rat | RGD:2592 | 25440 | ||||||
Dog | fatty acid binding protein 6 | VGNC:40562 | 479309 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fatty acid binding protein 6 | |||||
Macaque | fatty acid binding protein 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | fatty acid binding protein 6 | |||||
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (9)
Reactome (7)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Reactome | Recycling of bile acids and salts | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Recycling of bile acids and salts | ||||
Gene Ontology Terms (9)
Functions (2)
Components (3)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (64)
1 – 10 of 64
SLC10A2
Family: Transporter
Novelty: 0.0036213
Score: 0.982
Data Source: STRINGDB
NR1H4
Family: NR
Novelty: 0.00067092
Score: 0.973
Data Source: STRINGDB
FABP4
Novelty: 0.00107707
Score: 0.946
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.928
Data Source: Reactome,STRINGDB
ABCC3
Family: Transporter
Novelty: 0.00260166
Score: 0.926
Data Source: STRINGDB
RXRA
Family: NR
Novelty: 0.00244343
Score: 0.923
Data Source: STRINGDB
LIPE
Family: Enzyme
Novelty: 0.00169872
Score: 0.918
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.902
Data Source: STRINGDB
NCOA2
Novelty: 0.00510052
Score: 0.9
Data Source: STRINGDB
FABP2
Novelty: 0.00217814
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score 144.68
PubMed score by year
PubTator Score 58.9
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: