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Tbio
FABP6
Gastrotropin

Protein Summary
Description
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393980
  • ENSP00000377549
  • ENSG00000170231
  • ENST00000402432
  • ENSP00000385433

Symbol
  • ILBP
  • ILLBP
  • ILBP
  • I-15P
  • I-BAP
  • ILBP3
  • ILLBP
  • I-BABP
  • I-BALB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
transcription factor
0.64
disease perturbation
0.62
cell type or tissue
0.51
metabolite
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.68   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.68   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
86.5
mean platelet volume
1
1
1
37.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
86.5
mean platelet volume
1
37.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 6
VGNC:6871
107974918
Macaque
fatty acid binding protein 6
695439
Mouse
MGI:96565
16204
Rat
RGD:2592
25440
Dog
fatty acid binding protein 6
VGNC:40562
479309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 6
Macaque
fatty acid binding protein 6
Mouse
Rat
Dog
fatty acid binding protein 6
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Recycling of bile acids and salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Recycling of bile acids and salts
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
SLC10A2
Tclin
Family: Transporter
Novelty: 0.0036213
Score: 0.982
Data Source: STRINGDB
NR1H4
Tclin
Family: NR
Novelty: 0.00067092
Score: 0.973
Data Source: STRINGDB
FABP4
Tchem
Novelty: 0.00107707
Score: 0.946
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.928
Data Source: Reactome,STRINGDB
ABCC3
Tbio
Family: Transporter
Novelty: 0.00260166
Score: 0.926
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.923
Data Source: STRINGDB
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.918
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.902
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.9
Data Source: STRINGDB
FABP2
Tchem
Novelty: 0.00217814
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  144.68

PubMed score by year
PubTator Score  58.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer