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Tclin
PDE6C
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Protein Summary
Description
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371447
  • ENSP00000360502
  • ENSG00000095464

Symbol
  • PDEA2
  • COD4
  • ACHM5
  • PDEA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.88
protein domain
0.85
small molecule perturbation
0.56
cell type or tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.44   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.44   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
82.8
waist-hip ratio
3
5
6
80.9
vitamin A measurement
1
1
1
62.8
waist circumference
1
1
1
56.4
BMI-adjusted waist circumference
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
82.8
waist-hip ratio
6
80.9
vitamin A measurement
1
62.8
waist circumference
1
56.4
BMI-adjusted waist circumference
1
42.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6C
VGNC:7246
740456
Macaque
phosphodiesterase 6C
700261
Mouse
MGI:105956
110855
Rat
RGD:1309844
361752
Dog
phosphodiesterase 6C
VGNC:44359
486805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6C
Macaque
phosphodiesterase 6C
Mouse
Rat
Dog
phosphodiesterase 6C
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51160-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (108)
1 – 10 of 108
CNGB3
Tchem
Family:  IC
Novelty:  0.01174942
Score:  0.995
Data Source:  STRINGDB
PDE6H
Tclin
Family:  Enzyme
Novelty:  0.0524804
Score:  0.992
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.989
Data Source:  STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
Score:  0.982
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.943
Data Source:  STRINGDB
RGS9BP
Tbio
Novelty:  0.04608613
Score:  0.939
Data Source:  STRINGDB
GNG11
Tbio
Novelty:  0.10721743
Score:  0.93
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.912
Data Source:  STRINGDB
RGS9
Tbio
Novelty:  0.06662559
Score:  0.9
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.857
Data Source:  STRINGDB
Publication Statistics
PubMed Score  41.44

PubMed score by year
PubTator Score  21.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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