PDE6C
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein Summary
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]
- ENST00000371447
- ENSP00000360502
- ENSG00000095464
- PDEA2
- COD4
- ACHM5
- PDEA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
molecular function | 0.88 | ||
protein domain | 0.85 | ||
small molecule perturbation | 0.56 | ||
cell type or tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.44 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.44 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 32
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (32)
Protein-Protein Interactions (108)
Nearest Tclin Targets
Pathways (5)
KEGG (2)
PathwayCommons (2)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Metabolic pathways | ||||
KEGG | Purine metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolic pathways | ||||
Purine metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (1)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 5 | 6 | 82.8 | |||||
waist-hip ratio | 3 | 5 | 6 | 80.9 | |||||
vitamin A measurement | 1 | 1 | 1 | 62.8 | |||||
waist circumference | 1 | 1 | 1 | 56.4 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 82.8 | |||||
waist-hip ratio | 6 | 80.9 | |||||
vitamin A measurement | 1 | 62.8 | |||||
waist circumference | 1 | 56.4 | |||||
BMI-adjusted waist circumference | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphodiesterase 6C | VGNC:7246 | 740456 | |||||
Macaque | phosphodiesterase 6C | 700261 | ||||||
Mouse | MGI:105956 | 110855 | ||||||
Rat | RGD:1309844 | 361752 | ||||||
Dog | phosphodiesterase 6C | VGNC:44359 | 486805 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphodiesterase 6C | |||||
Macaque | phosphodiesterase 6C | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphodiesterase 6C | |||||
Publication Statistics
PubMed Score 41.44
PubMed score by year
PubTator Score 21.30
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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