Tclin PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Protein Summary

Description

As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P51160
• A6NCR6
• Q5VY29

Gene Name

• PDE6C

Ensembl ID

• ENST00000371447
• ENSP00000360502
• ENSG00000095464

Symbol

• PDEA2
• COD4
• ACHM5
• PDEA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
molecular function	0.88
protein domain	0.85
small molecule perturbation	0.56
cell type or tissue	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.47   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.47   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3