RAB27A
Ras-related protein Rab-27A
Protein Summary
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- ENST00000336787
- ENSP00000337761
- ENSG00000069974
- ENST00000396307
- ENSP00000379601
- ENST00000564609
- ENSP00000455012
- ENST00000569493
- ENSP00000456059
- RAB27
- GS2
- RAM
- RAB27
- HsT18676
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
molecular function | 0.96 | ||
biological process | 0.9 | ||
PubMedID | 0.88 | ||
histone modification site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.75 (req: < 5)
Gene RIFs: 119 (req: <= 3)
Antibodies: 416 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.75 (req: >= 5)
Gene RIFs: 119 (req: > 3)
Antibodies: 416 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0