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Tbio
RAB13
Ras-related protein Rab-13

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368575
  • ENSP00000357564
  • ENSG00000143545

Symbol
  • GIG4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.91
interacting protein
0.9
disease perturbation
0.87
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.86   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.86   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Gene Ontology Terms (31)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (153)
1 – 10 of 153
GDI1
Tbio
Novelty: 0.02210681
p_int: 0.999915601
p_ni: 0.000084397
p_wrong: 3e-9
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.10510475
p_int: 0.989596329
p_ni: 0.01039836
p_wrong: 0.000005311
Score: 0.98
Data Source: BioPlex,STRINGDB
RABIF
Tbio
Novelty: 0.63157895
p_int: 0.870051639
p_ni: 0.129948361
Score: 0.657
Data Source: BioPlex,STRINGDB
MYO5A
Tbio
Novelty: 0.00498077
Score: 0.963
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.03351296
Score: 0.95
Data Source: Reactome,STRINGDB
TBC1D4
Tbio
Novelty: 0.00751276
Score: 0.949
Data Source: STRINGDB
EXOC6
Tbio
Novelty: 0.02897817
Score: 0.947
Data Source: STRINGDB
DENND1C
Tbio
Novelty: 0.98130841
Score: 0.945
Data Source: STRINGDB
EXOC7
Tbio
Novelty: 0.01322945
Score: 0.945
Data Source: STRINGDB
TBC1D1
Tbio
Novelty: 0.0167459
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.86

PubMed score by year
PubTator Score  22.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer