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Tbio
RAB9A
Ras-related protein Rab-9A

Protein Summary
Description
Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000464506
  • ENSP00000420127
  • ENSG00000123595
  • ENST00000618931
  • ENSP00000480777

Symbol
  • RAB9
  • RAB9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
interacting protein
0.85
virus perturbation
0.72
cellular component
0.7
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.38   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.38   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
44.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB9A, member RAS oncogene family
VGNC:7628
465497
Macaque
RAB9A, member RAS oncogene family
720906
Mouse
MGI:1890695
56382
Rat
RGD:619740
84589
Dog
RAB9A, member RAS oncogene family
VGNC:45297
403947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB9A, member RAS oncogene family
Macaque
RAB9A, member RAS oncogene family
Mouse
Rat
Dog
RAB9A, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51151-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (190)
1 – 10 of 190
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999999999
p_ni:  1e-9
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.99999785
p_ni:  0.00000215
Score:  0.959
Data Source:  BioPlex,Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999974827
p_ni:  0.000008962
p_wrong:  0.00001621
Score:  0.955
Data Source:  BioPlex,Reactome,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.999361973
p_ni:  0.000638027
Score:  0.979
Data Source:  BioPlex,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
p_int:  0.999019754
p_ni:  0.000980246
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
VPS13C
Tbio
Novelty:  0.05207291
p_int:  0.99882438
p_ni:  0.001175618
p_wrong:  2e-9
Score:  0.401
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.991129035
p_ni:  0.008870964
p_wrong:  2e-9
Score:  0.934
Data Source:  BioPlex,STRINGDB
SPHK2
Tchem
Family:  Kinase
Novelty:  0.00454527
p_int:  0.987168536
p_ni:  0.000080397
p_wrong:  0.012751066
Score:  0.394
Data Source:  BioPlex,STRINGDB
RCVRN
Tbio
Novelty:  0.00266222
p_int:  0.984856209
p_ni:  0.015143785
p_wrong:  6e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.978748203
p_ni:  0.021251797
Data Source:  BioPlex
Publication Statistics
PubMed Score  15.38

PubMed score by year
PubTator Score  57.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer