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Tbio
RAB5C
Ras-related protein Rab-5C

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity). Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346213
  • ENSP00000345689
  • ENSG00000108774
  • ENST00000393860
  • ENSP00000377440
  • ENST00000547517
  • ENSP00000447053

Symbol
  • RABL
  • RABL
  • L1880
  • RAB5L
  • RAB5CL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.93
disease perturbation
0.9
histone modification site profile
0.81
gene perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.16   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.16   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
51.6
fibrinogen measurement
3
1
3
41.7
1
1
0
1.2
40.1
Thyroid preparation use measurement
1
1
1
37.9
leukocyte count
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
51.6
fibrinogen measurement
3
41.7
0
1.2
40.1
Thyroid preparation use measurement
1
37.9
leukocyte count
1
7.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB5C, member RAS oncogene family
VGNC:14189
454678
Mouse
MGI:105306
19345
Rat
RGD:1307095
287709
Dog
RAB5C, member RAS oncogene family
403941
Horse
RAB5C, member RAS oncogene family
VGNC:49530
100053004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB5C, member RAS oncogene family
Mouse
Rat
Dog
RAB5C, member RAS oncogene family
Horse
RAB5C, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51148-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Immune System
Innate Immune System
Membrane Trafficking
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (329)
1 – 10 of 329
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01387591
p_int: 0.999856493
p_ni: 0.000143507
Score: 0.588
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999854616
p_ni: 0.000145384
Score: 0.965
Data Source: BioPlex,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999850589
p_ni: 0.000149411
Score: 0.98
Data Source: BioPlex,STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
p_int: 0.997214725
p_ni: 0.00019126
p_wrong: 0.002594015
Score: 0.5
Data Source: BioPlex,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.993229546
p_ni: 0.006699447
p_wrong: 0.000071007
Score: 0.975
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
p_int: 0.951398768
p_ni: 0.048601232
Score: 0.991
Data Source: BioPlex,STRINGDB
EEA1
Tbio
Novelty: 0.00242832
Score: 0.991
Data Source: STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.99
Data Source: STRINGDB
RAB7A
Tbio
Family: Enzyme
Novelty: 0.00192702
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.16

PubMed score by year
PubTator Score  16.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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