Tbio RAB5C Ras-related protein Rab-5C

Protein Summary

Description

Protein transport. Probably involved in vesicular traffic (By similarity). Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• P51148
• F8W1H5
• Q6FH55
• Q9P0Y5

Gene Name

• RAB5C

Ensembl ID

• ENST00000346213
• ENSP00000345689
• ENSG00000108774
• ENST00000393860
• ENSP00000377440
• ENST00000547517
• ENSP00000447053

Symbol

• RABL
• RABL
• L1880
• RAB5L
• RAB5CL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
molecular function	0.93
disease perturbation	0.9
histone modification site profile	0.81
gene perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0