Tbio FXR2 Fragile X mental retardation syndrome-related protein 2

Protein Summary

Description

RNA-binding protein. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51116
• B2R9M2
• D3DTQ1
• Q86V09
• Q8WUM2

Gene Name

• FXR2

Ensembl ID

• ENST00000250113
• ENSP00000250113
• ENSG00000129245

Symbol

• FMR1L2
• FXR2P
• FMR1L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
transcription factor	0.74
transcription factor binding site profile	0.72
drug perturbation	0.71
tissue sample	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0