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Tbio
FXR2
Fragile X mental retardation syndrome-related protein 2

Protein Summary
Description
RNA-binding protein. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250113
  • ENSP00000250113
  • ENSG00000129245

Symbol
  • FMR1L2
  • FXR2P
  • FMR1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
transcription factor
0.74
transcription factor binding site profile
0.72
drug perturbation
0.71
tissue sample
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
66.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
66.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FMR1 autosomal homolog 2
VGNC:9300
749002
Macaque
FMR1 autosomal homolog 2
721889
Mouse
MGI:1346074
23879
Rat
RGD:1307011
287433
Dog
FMR1 autosomal homolog 2
VGNC:53386
489478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FMR1 autosomal homolog 2
Macaque
FMR1 autosomal homolog 2
Mouse
Rat
Dog
FMR1 autosomal homolog 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51116-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (127)
1 – 10 of 127
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.998168817
p_ni: 0.001831183
Data Source: BioPlex
FMR1
Tbio
Family: Epigenetic
Novelty: 0.00032203
p_int: 0.997928117
p_ni: 0.002071883
Score: 0.949
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.997099136
p_ni: 0.002900864
Score: 0.164
Data Source: BioPlex,STRINGDB
SNX1
Tbio
Novelty: 0.01267973
p_int: 0.993743166
p_ni: 0.006256833
p_wrong: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty: 0.0025302
p_int: 0.975754626
p_ni: 0.024245374
Score: 0.216
Data Source: BioPlex,STRINGDB
BTBD1
Tbio
Novelty: 0.19772296
p_int: 0.974871516
p_ni: 0.025128474
p_wrong: 1e-8
Data Source: BioPlex
FXR1
Tbio
Novelty: 0.01279428
p_int: 0.971236919
p_ni: 0.02876307
p_wrong: 1.1e-8
Score: 0.964
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.93895419
p_ni: 0.06104581
Score: 0.261
Data Source: BioPlex,STRINGDB
NUP214
Tbio
Novelty: 0.00924336
p_int: 0.936939963
p_ni: 0.063060037
Score: 0.195
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.897316144
p_ni: 0.102683856
Data Source: BioPlex
Publication Statistics
PubMed Score  33.67

PubMed score by year
PubTator Score  19.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer