Tbio FXR1 Fragile X mental retardation syndrome-related protein 1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 1

Protein Summary

Description

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51114
• A8K9B8
• Q7Z450
• Q8N6R8
• hFXR1p

Gene Name

• FXR1

Ensembl ID

• ENST00000305586
• ENSP00000307633
• ENSG00000114416
• ENST00000357559
• ENSP00000350170
• ENST00000445140
• ENSP00000388828

Symbol

• FXR1P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.96
kinase perturbation	0.95
interacting protein	0.9
transcription factor binding site profile	0.77

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.25   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.25   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	4	3	1	1.1	76.7
self reported educational attainment	EFO_0004784	1	1	1		20.2
intelligence	EFO_0004337	1	1	1		20.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	1	1.1	76.7
self reported educational attainment	EFO_0004784	1		20.2
intelligence	EFO_0004337	1		20.2

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	FMR1 autosomal homolog 1		746398
Macaque	FMR1 autosomal homolog 1		710170
Mouse	fragile X mental retardation gene 1, autosomal homolog	MGI:104860	14359
Dog	FMR1 autosomal homolog 1	VGNC:53461	100855907
Horse	FMR1 autosomal homolog 1		100066076

Species	Name	OMA	EggNOG	Inparanoid
Chimp	FMR1 autosomal homolog 1
Macaque	FMR1 autosomal homolog 1
Mouse	fragile X mental retardation gene 1, autosomal homolog
Dog	FMR1 autosomal homolog 1
Horse	FMR1 autosomal homolog 1

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (83)

Reactome (4)

KEGG (1)

WikiPathways (78)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	Oncogenic MAPK signaling	79 targets	R-HSA-6802957
Reactome	Signaling by BRAF and RAF fusions	63 targets	R-HSA-6802952

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
Oncogenic MAPK signaling	79 targets	R-HSA-6802957
Signaling by BRAF and RAF fusions	63 targets	R-HSA-6802952

Gene Ontology Terms (29)

Functions (7)

Components (15)

Processes (7)

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10

1 – 7 of 7

GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA strand annealing activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (187)

Explore Interacting Targets

1 – 10 of 187

• See Interactions on String-DB

LGALS3BP

Tbio

Novelty: 0.0025302

p_int: 0.997015163

p_ni: 0.002984837

Score: 0.161

Data Source: BioPlex,STRINGDB

RRP8

Tbio

Family: Enzyme

Novelty: 0.04922797

p_int: 0.985506263

p_ni: 0.014493737

Score: 0.151

Data Source: BioPlex,STRINGDB

FXR2

Tbio

Family: Epigenetic

Novelty: 0.0253623

p_int: 0.971236919

p_ni: 0.02876307

p_wrong: 1.1e-8

Score: 0.964

Data Source: BioPlex,STRINGDB

GPSM3

Tbio

Novelty: 0.01632501

p_int: 0.965914561

p_ni: 0.034085439

Data Source: BioPlex

MAP7

Tbio

Novelty: 0.01976296

p_int: 0.952103855

p_ni: 0.047896145

Data Source: BioPlex

MAGEA4

Tbio

Novelty: 0.00949096

p_int: 0.948251564

p_ni: 0.051748436

Score: 0.195

Data Source: BioPlex,STRINGDB

PINX1

Tbio

Family: TF

Novelty: 0.01237398

p_int: 0.945056657

p_ni: 0.054943343

Score: 0.228

Data Source: BioPlex,STRINGDB

PLEKHO1

Tbio

Novelty: 0.01658553

p_int: 0.914213198

p_ni: 0.085786802

Data Source: BioPlex

CHCHD4

Tbio

Novelty: 0.01204944

p_int: 0.853766282

p_ni: 0.146233718

Data Source: BioPlex

ZNF512

Tbio

Family: TF

Novelty: 0.08783629

p_int: 0.845122008

p_ni: 0.154877992

Data Source: BioPlex

Publication Statistics

PubMed Score  85.25

PubMed score by year

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PubTator Score  42.72

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Isopeptide bond
Myogenesis

GWAS Trait Find Similar Targets

intelligence
schizophrenia
self reported educational attainment

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
muscle phenotype
reproductive system phenotype
respiratory system phenotype