Tbio FXR1 Fragile X mental retardation syndrome-related protein 1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Fragile X Mental Retardation Syndrome-related Protein 1

Protein Summary

Description

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51114
• A8K9B8
• Q7Z450
• Q8N6R8
• hFXR1p

Gene Name

• FXR1

Ensembl ID

• ENST00000305586
• ENSP00000307633
• ENSG00000114416
• ENST00000357559
• ENSP00000350170
• ENST00000445140
• ENSP00000388828

Symbol

• FXR1P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.96
kinase perturbation	0.95
interacting protein	0.9
transcription factor binding site profile	0.77

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.67   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.67   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (83)

Reactome (4)

KEGG (1)

WikiPathways (78)

Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	Oncogenic MAPK signaling	79 targets	R-HSA-6802957
Reactome	Signaling by BRAF and RAF fusions	63 targets	R-HSA-6802952

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
Oncogenic MAPK signaling	79 targets	R-HSA-6802957
Signaling by BRAF and RAF fusions	63 targets	R-HSA-6802952

Gene Ontology Terms (29)

Functions (7)

Components (15)

Processes (7)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA strand annealing activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (187)

Explore Interacting Targets

1 – 10 of 187

• See Interactions on String-DB

LGALS3BP

Tbio

Novelty: 0.00116733

p_int: 0.997015163

p_ni: 0.002984837

Score: 0.161

Data Source: BioPlex,STRINGDB

RRP8

Tbio

Family: Enzyme

Novelty: 0.00456854

p_int: 0.985506263

p_ni: 0.014493737

Score: 0.151

Data Source: BioPlex,STRINGDB

FXR2

Tbio

Family: Epigenetic

Novelty: 0.04147056

p_int: 0.971236919

p_ni: 0.02876307

p_wrong: 1.1e-8

Score: 0.964

Data Source: BioPlex,STRINGDB

GPSM3

Tbio

Novelty: 0.0098187

p_int: 0.965914561

p_ni: 0.034085439

Data Source: BioPlex

MAP7

Tbio

Novelty: 0.02738196

p_int: 0.952103855

p_ni: 0.047896145

Data Source: BioPlex

MAGEA4

Tbio

Novelty: 0.00987373

p_int: 0.948251564

p_ni: 0.051748436

Score: 0.195

Data Source: BioPlex,STRINGDB

PINX1

Tbio

Family: TF

Novelty: 0.00961502

p_int: 0.945056657

p_ni: 0.054943343

Score: 0.228

Data Source: BioPlex,STRINGDB

PLEKHO1

Tbio

Novelty: 0.01414157

p_int: 0.914213198

p_ni: 0.085786802

Data Source: BioPlex

CHCHD4

Tbio

Novelty: 0.01246396

p_int: 0.853766282

p_ni: 0.146233718

Data Source: BioPlex

ZNF512

Tbio

Family: TF

Novelty: 0.19294377

p_int: 0.845122008

p_ni: 0.154877992

Data Source: BioPlex

Publication Statistics

PubMed Score  61.67

PubMed score by year

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PubTator Score  42.72

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSR

1-70

ANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREA

70-140

CANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLE

140-210

CTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLE

210-280

FVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVL

280-350

LEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELS

350-420

DWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTAD

420-490

TDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAK

490-560

NKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS

560-621

MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Isopeptide bond
Myogenesis