FXR1
Fragile X mental retardation syndrome-related protein 1
Protein Summary
RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000305586
- ENSP00000307633
- ENSG00000114416
- ENST00000357559
- ENSP00000350170
- ENST00000445140
- ENSP00000388828
- FXR1P
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
virus perturbation | 0.96 | ||
kinase perturbation | 0.95 | ||
interacting protein | 0.9 | ||
transcription factor binding site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.89 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.89 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (187)
LGALS3BP
Novelty: 0.0025302
p_int: 0.997015163
p_ni: 0.002984837
Score: 0.161
Data Source: BioPlex,STRINGDB
RRP8
Family: Enzyme
Novelty: 0.04922797
p_int: 0.985506263
p_ni: 0.014493737
Score: 0.151
Data Source: BioPlex,STRINGDB
FXR2
Family: Epigenetic
Novelty: 0.0253623
p_int: 0.971236919
p_ni: 0.02876307
p_wrong: 1.1e-8
Score: 0.964
Data Source: BioPlex,STRINGDB
MAGEA4
Novelty: 0.00949096
p_int: 0.948251564
p_ni: 0.051748436
Score: 0.195
Data Source: BioPlex,STRINGDB
PINX1
Family: TF
Novelty: 0.01237398
p_int: 0.945056657
p_ni: 0.054943343
Score: 0.228
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (83)
Reactome (4)
KEGG (1)
WikiPathways (78)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Oncogenic MAPK signaling | ||||
Reactome | Signaling by BRAF and RAF fusions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of signal transduction | ||||
Oncogenic MAPK signaling | ||||
Signaling by BRAF and RAF fusions | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (7)
Components (15)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 4 | 3 | 1.1 | 71.9 | |||||
self reported educational attainment | 2 | 2 | 2 | 68.4 | |||||
1 | 1 | 1 | 35 | ||||||
1 | 1 | 1 | 31.4 | ||||||
intelligence | 1 | 1 | 1 | 26.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 1.1 | 71.9 | |||||
self reported educational attainment | 2 | 68.4 | |||||
1 | 35 | ||||||
1 | 31.4 | ||||||
intelligence | 1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | FMR1 autosomal homolog 1 | 746398 | ||||||
Macaque | FMR1 autosomal homolog 1 | 710170 | ||||||
Mouse | MGI:104860 | 14359 | ||||||
Dog | FMR1 autosomal homolog 1 | VGNC:53461 | 100855907 | |||||
Horse | FMR1 autosomal homolog 1 | 100066076 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | FMR1 autosomal homolog 1 | |||||
Macaque | FMR1 autosomal homolog 1 | |||||
Mouse | ||||||
Dog | FMR1 autosomal homolog 1 | |||||
Horse | FMR1 autosomal homolog 1 | |||||
Publication Statistics
PubMed Score 88.89
PubMed score by year
PubTator Score 42.72
PubTator score by year
Related Publications
Text Mined References (63)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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