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Tbio
PAPOLA
Poly(A) polymerase alpha

Protein Summary
Description
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216277
  • ENSP00000216277
  • ENSG00000090060
  • ENST00000557320
  • ENSP00000450437

Symbol
  • PAP
  • PAP
  • PAP-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
molecular function
0.96
transcription factor binding site profile
0.86
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (314)
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
p_int:  0.789742642
p_ni:  0.171815763
p_wrong:  0.038441595
Score:  0.208
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.789288073
p_ni:  0.000037597
p_wrong:  0.21067433
Score:  0.183
Data Source:  BioPlex,STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
Score:  0.999
Data Source:  STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.998
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.997
Data Source:  STRINGDB
CSTF2
Tbio
Novelty:  0.01389909
Score:  0.994
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.992
Data Source:  STRINGDB
CSTF2T
Tbio
Novelty:  0.11811814
Score:  0.992
Data Source:  STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.991
Data Source:  STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
2
2
72.1
fertility measurement
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
72.1
fertility measurement
1
1.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) polymerase alpha
VGNC:3361
100614622
Macaque
poly(A) polymerase alpha
641447
Mouse
MGI:109301
18789
Rat
RGD:1308673
314417
Dog
poly(A) polymerase alpha
VGNC:50551
480430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) polymerase alpha
Macaque
poly(A) polymerase alpha
Mouse
Rat
Dog
poly(A) polymerase alpha
Publication Statistics
PubMed Score 8.38
PubMed score by year
PubTator Score 27.48
PubTator score by year
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Related Publications
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PMID
Year
Title