PAPOLA
Poly(A) polymerase alpha
Protein Summary
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000216277
- ENSP00000216277
- ENSG00000090060
- ENST00000557320
- ENSP00000450437
- PAP
- PAP
- PAP-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.96 | ||
transcription factor binding site profile | 0.86 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.38 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.38 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (314)
Nearest Tclin Targets
Pathways (14)
Reactome (10)
KEGG (1)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | Processing of Intronless Pre-mRNAs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
Processing of Intronless Pre-mRNAs | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 2 | 2 | 72.1 | |||||
fertility measurement | 1 | 1 | 1 | 1.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 2 | 72.1 | |||||
fertility measurement | 1 | 1.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | poly(A) polymerase alpha | VGNC:3361 | 100614622 | |||||
Macaque | poly(A) polymerase alpha | 641447 | ||||||
Mouse | MGI:109301 | 18789 | ||||||
Rat | RGD:1308673 | 314417 | ||||||
Dog | poly(A) polymerase alpha | VGNC:50551 | 480430 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | poly(A) polymerase alpha | |||||
Macaque | poly(A) polymerase alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | poly(A) polymerase alpha | |||||
Publication Statistics
PubMed Score 8.38
PubMed score by year
PubTator Score 27.48
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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