PAPOLA
Poly(A) polymerase alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.96 | ||
transcription factor binding site profile | 0.86 | ||
disease perturbation | 0.74 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | Processing of Intronless Pre-mRNAs | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
Processing of Intronless Pre-mRNAs | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 2 | 2 | 72.1 | |||||
fertility measurement | 1 | 1 | 1 | 1.6 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
C-reactive protein measurement | 2 | 72.1 | |||||
fertility measurement | 1 | 1.6 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | poly(A) polymerase alpha | VGNC:3361 | 100614622 | |||||
Macaque | poly(A) polymerase alpha | 641447 | ||||||
Mouse | MGI:109301 | 18789 | ||||||
Rat | RGD:1308673 | 314417 | ||||||
Dog | poly(A) polymerase alpha | VGNC:50551 | 480430 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | poly(A) polymerase alpha | |||||
Macaque | poly(A) polymerase alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | poly(A) polymerase alpha | |||||
PMID | Year | Title |
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