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Tclin
ATP1A2
Sodium/potassium-transporting ATPase subunit alpha-2

Protein Summary
Description
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361216
  • ENSP00000354490
  • ENSG00000018625

Symbol
  • KIAA0778
  • FHM2
  • MHP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.98
disease perturbation
0.93
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.25   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.25   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
15.1
Pathways (25)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (52)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
P2RY8
Tbio
Family: GPCR
Novelty: 0.05574297
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.999999988
p_ni: 9e-9
p_wrong: 3e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.999999839
p_ni: 1.61e-7
Data Source: BioPlex
ARHGEF16
Tbio
Novelty: 0.01856936
p_int: 0.999999656
p_ni: 3.41e-7
p_wrong: 3e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
ROGDI
Tbio
Novelty: 0.077277
p_int: 0.999960708
p_ni: 7.92e-7
p_wrong: 0.000038501
Score: 0.409
Data Source: BioPlex,STRINGDB
ATP1B1
Tclin
Family: Transporter
Novelty: 0.025056
Score: 0.991
Data Source: Reactome,STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.02641193
Score: 0.982
Data Source: Reactome,STRINGDB
FXYD2
Tclin
Family: Enzyme
Novelty: 0.0196518
Score: 0.968
Data Source: STRINGDB
ATP1B3
Tclin
Family: Transporter
Novelty: 0.06773518
Score: 0.964
Data Source: Reactome,STRINGDB
FXYD6
Tbio
Family: IC
Novelty: 0.0503209
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  169.25

PubMed score by year
PubTator Score  128.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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